Structure of PDB 5oc9 Chain A Binding Site BS02

Receptor Information
>5oc9 Chain A (length=607) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SFTPLVVIELAQDVKEETKEWLKNRIIAKKKDGGAQLLFRPLLQNLYLVG
ASKIRMLLGAEAVGLVKECNDNTMRAFTYRTRQNFKGFDDNNDDFLTMAE
CQFIIKHELENLRAKDEKMIPGYPQAKLYPGKSLLRRLLTSGIVIQVFPL
HDSEALKKLEDTWYLKYQPIDSIRGYFGETIALYFGFLEYFTFALIPMAV
IGLPYYLFVWEDYDKYVIFASFNLIWSTVILELWKRGCANMTYRWGTLLM
KRKFEEPRPGFHGVLGINSITGKEEPLYPSYKRQLRIYLVSLPFVCLCLY
FSLYVMMIYFDMEVWALGLHENSEWTSVLLYVPSIIYAIVIEIMNRLYRY
AAEFLTSWENHRLESAYQNHLILKVLVFNFLNCFASLFYIAFVLKDMKLL
RQSLATLLITSQILNQIMESFLPYWLQRKHGVRVKRKVQALKDATLYEQV
ILEKEMGTYLGTFDDYLELFLQFGYVSLFSCVYPLAAAFAVLNNFTEVNS
DALKMCRVFKRPFSEPSANIGVWQLAFETMSVISVVTNCALIGMSPQVNA
VFPESKADLILIVVAVEHALLALKFILAFAIPDKPRHIQMKLARLEFESL
EALKQQQ
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain5oc9 Chain A Residue 702 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5oc9 The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		E448 D497 E500 E529 D533
Binding residue
(residue number reindexed from 1)		E419 D465 E468 E497 D501
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005227 calcium-activated cation channel activity
GO:0005229 intracellularly calcium-gated chloride channel activity
GO:0005254 chloride channel activity
Biological Process
GO:0034220 monoatomic ion transmembrane transport
GO:0098655 monoatomic cation transmembrane transport
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0043231 intracellular membrane-bounded organelle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5oc9, PDBe:5oc9, PDBj:5oc9
PDBsum5oc9
PubMed31477691
UniProtQ9NW15|ANO10_HUMAN Anoctamin-10 (Gene Name=ANO10)

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