Structure of PDB 5nva Chain A Binding Site BS02

Receptor Information
>5nva Chain A (length=472) Species: 529507 (Proteus mirabilis HI4320) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DFGFINYAVLFGYLAAMLLVGVYFSKRQKTADDYFRGGGRVPGWAAGVSV
FATTLSSITFMSIPAKAYTSDWTFIIGQYLAIAILPLVFYFYIPFFRKLK
ITSAYEYLEARFDVRSRLFASLSFMLFHIGRVAIITYLTVLALRPFMGID
PVVLIVLISLLCIIYTWMGGIEGVIWTDVIQGLLLSGGAVLIFIMICFKV
DGGISEIFTTTAQADKFFPTTQWRWSWTDSTIPVLMIGFLFANIQQFTAS
QDVVQRYIVTDSIKETKRTLITNAKLVAIIPIFFFAIGSALFVYYQQNPS
LLPAGFNTGGILPLFIVTEMPIGIAGLIIAAIFAAAQSSISSSLNSISSC
FNSDIYTRLSKSSPSPEQKMKVAKLVIIVAGIFSSLAAIWLVLSSLIGLM
GGPMTGLFMLGIFVKRANAGSAVVGIIVSIIAVLAARYGSDLNFFFYGVI
GSMSVVIAGTITAPLFAPAKQL
Ligand information
Ligand IDNA
InChIInChI=1S/Na/q+1
InChIKeyFKNQFGJONOIPTF-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[Na+]
FormulaNa
NameSODIUM ION
ChEMBL
DrugBankDB14516
ZINC
PDB chain5nva Chain A Residue 502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5nva Substrate-bound outward-open structure of a Na+-coupled sialic acid symporter reveals a new Na+site.
Resolution2.26 Å
Binding residue
(original residue number in PDB)		V178 D182 S342 S345 S346
Binding residue
(residue number reindexed from 1)		V174 D178 S338 S341 S342
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0015293 symporter activity
GO:0022857 transmembrane transporter activity
Biological Process
GO:0006814 sodium ion transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5nva, PDBe:5nva, PDBj:5nva
PDBsum5nva
PubMed29717135
UniProtB4EZY7|SIAT_PROMH Sodium/sialic acid symporter SiaT (Gene Name=siaT)

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