Structure of PDB 5n6i Chain A Binding Site BS02
Receptor Information
>5n6i Chain A (length=357) Species:
10090
(Mus musculus) [
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KLKKVLDKLRLKRKDISEAAETVNKVVERLLRRMQKRESEFKGVEQLNTG
SYYEHVKISAPNEFDVMFKLEVPRIELQEYYETGAFYLVKFKRIPRGNPL
SHFLEGEVLSATKMLSKFRKIIKEEVKEIKDIDVSVEKEKPGSPAVTLLI
RNPEEISVDIILALESKGSWPISTKEGLPIQGWLGTKVRTNLRREPFYLV
PKNAKDGNSFQGETWRLSFSHTEKYILNNHGIEKTCCESSGAKCCRKECL
KLMKYLLEQLKKEFQELDAFCSYHVKTAIFHMWTQDPQDSQWDPRNLSSC
FDKLLAFFLECLRTEKLDHYFIPKFNLFSQELIDRKSKEFLSKKIEYERN
NGFPIFD
Ligand information
>5n6i Chain H (length=36) [
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atcatgtacagatcagtcatagatcactagtagatc
Receptor-Ligand Complex Structure
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PDB
5n6i
cGAS senses long and HMGB/TFAM-bound U-turn DNA by forming protein-DNA ladders.
Resolution
3.6 Å
Binding residue
(original residue number in PDB)
R158 K160 R161 R180 H203 K395
Binding residue
(residue number reindexed from 1)
R10 K12 R13 R32 H55 K247
Enzymatic activity
Enzyme Commision number
2.7.7.86
: cyclic GMP-AMP synthase.
External links
PDB
RCSB:5n6i
,
PDBe:5n6i
,
PDBj:5n6i
PDBsum
5n6i
PubMed
28902841
UniProt
Q8C6L5
|CGAS_MOUSE Cyclic GMP-AMP synthase (Gene Name=Cgas)
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