Structure of PDB 5n26 Chain A Binding Site BS02

Receptor Information
>5n26 Chain A (length=174) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ASTSQVRQNYHQDSEAAINRQINLELYASYVYLSMSYYFDRDDVALKNFA
KYFLHQSHEEREHAEKLMKLQNQRGGRIFLQDIKKPDCDDWESGLNAMEC
ALHLEKNVNQSLLELHKLATDKNDPHLCDFIETHYLNEQVKAIKELGDHV
TNLRKMGAPESGLAEYLFDKHTLG
Ligand information
Ligand ID73M
InChIInChI=1S/ClH.2H2N.H2O.Pt/h1H;3*1H2;/q;2*-1;;+4/p-2
InChIKeyDOKMFIMZADYDDQ-UHFFFAOYSA-L
SMILES
SoftwareSMILES
CACTVS 3.385N[Pt@@](N)(O)Cl
CACTVS 3.385
OpenEye OEToolkits 2.0.5		N[Pt](N)(O)Cl
FormulaCl H5 N2 O Pt
Namebis(azanyl)-chloranyl-oxidanyl-platinum
ChEMBL
DrugBank
ZINC
PDB chain5n26 Chain A Residue 202 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB5n26 Cisplatin Binding Sites in Human H-Chain Ferritin.
Resolution2.05 Å
Binding residue
(original residue number in PDB)		H105 N109
Binding residue
(residue number reindexed from 1)		H103 N107
Annotation score1
Enzymatic activity
Enzyme Commision number 1.16.3.1: ferroxidase.
Gene Ontology
Molecular Function
GO:0004322 ferroxidase activity
GO:0005506 iron ion binding
GO:0005515 protein binding
GO:0008198 ferrous iron binding
GO:0008199 ferric iron binding
GO:0016491 oxidoreductase activity
GO:0042802 identical protein binding
GO:0046872 metal ion binding
GO:0140315 iron ion sequestering activity
Biological Process
GO:0006826 iron ion transport
GO:0006879 intracellular iron ion homeostasis
GO:0006880 intracellular sequestering of iron ion
GO:0006955 immune response
GO:0008285 negative regulation of cell population proliferation
GO:0048147 negative regulation of fibroblast proliferation
GO:0110076 negative regulation of ferroptosis
Cellular Component
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005776 autophagosome
GO:0005829 cytosol
GO:0016020 membrane
GO:0031410 cytoplasmic vesicle
GO:0044754 autolysosome
GO:0070062 extracellular exosome
GO:0070288 ferritin complex
GO:1904724 tertiary granule lumen
GO:1904813 ficolin-1-rich granule lumen

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5n26, PDBe:5n26, PDBj:5n26
PDBsum5n26
PubMed28737381
UniProtP02794|FRIH_HUMAN Ferritin heavy chain (Gene Name=FTH1)

[Back to BioLiP]