Structure of PDB 5mxx Chain A Binding Site BS02

Receptor Information

>5mxx Chain A (length=361) Species: 9606 (Homo sapiens)

QEDPNDYCKGGYHLVKIGDLFNGRYHVIRKLGWGHFSTVWLSWDIQGKKF
VAMKVVKSAEHYTETALDEIRLLKSVRNSDPNDPNREMVVQLLDDFKISG
VNGTHICMVFEVLGHHLLKWIIKSNYQGLPLPCVKKIIQQVLQGLDYLHT
KCRITHTDIKPENILLSVNEQYIRRLAAEATENFLVNPLEPKNAEKLKVK
IADLGNACWVHKHFTEDIQTRQYRSLEVLIGSGYNTPADIWSTACMAFEL
ATGDYLFEPHSGEEYTRDEDHIALIIELLGKVPRKLIVAGKYSKEFFTKK
GDLKHITKLKPWGLFEVLVEKYEWSQEEAAGFTDFLLPMLELIPEKRATA
AECLRHPWLNS

Ligand information

• Ligand ID: CA
• InChI: InChI=1S/Ca/q+2
• InChIKey: BHPQYMZQTOCNFJ-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Ca++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Ca+2]
• Formula: Ca
• Name: CALCIUM ION
• DrugBank: DB14577
• PDB chain: 5mxx Chain A Residue 714

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5mxx Development of Potent, Selective SRPK1 Inhibitors as Potential Topical Therapeutics for Neovascular Eye Disease.
• Resolution: 1.75 Å
• Binding residue (original residue number in PDB): E614 E617
• Binding residue (residue number reindexed from 1): E320 E323
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): D213
• Catalytic site (residue number reindexed from 1): D158
• Enzyme Commision number: 2.7.11.1: non-specific serine/threonine protein kinase.

Gene Ontology

Molecular Function

• GO:0004672 protein kinase activity
• GO:0005524 ATP binding

Biological Process

• GO:0006468 protein phosphorylation

External links

• PDB: RCSB:5mxx, PDBe:5mxx, PDBj:5mxx
• PDBsum: 5mxx
• PubMed: 28135068
• UniProt: Q96SB4|SRPK1_HUMAN SRSF protein kinase 1 (Gene Name=SRPK1)