Structure of PDB 5mvf Chain A Binding Site BS02

Receptor Information
>5mvf Chain A (length=375) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GGSQTVTGGLRSLYQRKVLPLEEAYRFHEFHSPALEDADFENKPMILLVG
QYSTGKTTFIRYLLEQDFPGMRIDSFIAVMYGETEGSTPGNALVVDPKKP
FRKLSRFGNAFLNRFMCSQLPNQVLKSISIIDSPGILSRISRGYDFCQVL
QWFAERVDRIILLFDAHKLDISDEFSEAIKAFRGQDDKIRVVLNKADQVD
TQQLMRVYGALMWSLGKVINTPEVLRVYIGSFWAQPLQNTDNRRLFEAEA
QDLFRDIQSLPQKAAVRKLNDLIKRARLAKVHAYIISYLKKEMPNMFGKE
NKKRELIYRLPEIYVQLQREYQISAGDFPEVKAMQEQLENYDFTKFHSLK
PKLIEAVDNMLTNKISSLMGLISQE
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain5mvf Chain A Residue 602 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5mvf Structural insights into the activation mechanism of dynamin-like EHD ATPases.
Resolution3.268 Å
Binding residue
(original residue number in PDB)		T75 D156
Binding residue
(residue number reindexed from 1)		T57 D132
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0005525 GTP binding
GO:0046872 metal ion binding
Biological Process
GO:0006907 pinocytosis
GO:0030100 regulation of endocytosis
GO:0032456 endocytic recycling
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0051260 protein homooligomerization
GO:0071363 cellular response to growth factor stimulus
Cellular Component
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0031901 early endosome membrane
GO:0048471 perinuclear region of cytoplasm
GO:0055038 recycling endosome membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5mvf, PDBe:5mvf, PDBj:5mvf
PDBsum5mvf
PubMed28228524
UniProtQ9EQP2|EHD4_MOUSE EH domain-containing protein 4 (Gene Name=Ehd4)

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