Structure of PDB 5mko Chain A Binding Site BS02

Receptor Information
>5mko Chain A (length=308) Species: 70601 (Pyrococcus horikoshii OT3) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SMKCKFCSREAYIKIHYPKMYLCEEHFKEYFERKVSRTIERYKLLTKDER
ILVAVSGGKDSAVTAYVLKKLGYNIECLHINLGISGYSEKSEEYAKKQCK
LIGAPLHIVRIKEILGYGIGEVKTRRPPCSYCGLTKRYIMNKFAYDNGFD
AIATGHNLDDEASFLLNNILHWNTEYLAKGGPILPQQGKFIKKVKPLYEV
TEREVVAYALAVGLEYIVEECPYARGATTLDMKGVLNELEEKRPGTKFNF
VRGYLKKKKLFEPEIKEKEIKECKICRMPSSGDICAFCKFWGLKKEINFK
VSSTDEEP
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain5mko Chain A Residue 402 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5mko Nonredox thiolation in tRNA occurring via sulfur activation by a [4Fe-4S] cluster.
Resolution2.65 Å
Binding residue
(original residue number in PDB)		C3 C22 H25
Binding residue
(residue number reindexed from 1)		C4 C23 H26
Annotation score1
Enzymatic activity
Enzyme Commision number 2.8.1.-
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0005524 ATP binding
GO:0016740 transferase activity
GO:0046872 metal ion binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0002098 tRNA wobble uridine modification
GO:0002143 tRNA wobble position uridine thiolation
GO:0008033 tRNA processing
GO:0034227 tRNA thio-modification
Cellular Component
GO:0002144 cytosolic tRNA wobble base thiouridylase complex

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Biological Process
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Cellular Component
External links
PDB RCSB:5mko, PDBe:5mko, PDBj:5mko
PDBsum5mko
PubMed28655838
UniProtO58038|TTUA_PYRHO tRNA-5-methyluridine(54) 2-sulfurtransferase (Gene Name=ttuA)

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