Structure of PDB 5m3j Chain A Binding Site BS02

Receptor Information
>5m3j Chain A (length=716) Species: 1601067 (Influenza B virus (B/Memphis/13/2003)) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SMDTFITRNFQTTIIQKAKNTMAEFSEDPELQPAMLFNICVHLEVCYVIS
DMNFLDEEGKAYTAQNLRPQYEVIEGMPRTIAWMVQRSLAQEHGIETPKY
LADLFDYKTKRFIEVGITKGLADDYFWKKKEKLGNSMELMIFSYNQDYSL
SNESSLDEEGKGRVLSRLTELQAELSLKNLWQVLIGEEDVEKGIDFKLGQ
TISRLRDISVPAGFSNFEGMRSYIDNIDPKGAIERNLARMSPLVSVTPKK
LTWEDLRPIGPHIYNHELPEVPYNAFLLMSDELGLANMTEGKSKKPKTLA
KECLEKYSTLRDQTDPILIMKSEKANENFLWKLWRDCVNTISNEEMSNEL
QKTNYAKWATGDGLTYQKIMKEVAIDDETMCQEEPKIPNKCRVAAWVQTE
MNLLSTLTSKRALDLPEIGPDVAPVEHVGSERRKYFVNEINYCKASTVMM
KYVLFHTSLLNESNASMGKYKVIPITNRVVNEKGESFDMLYGLAVKGQSH
LRGDTDVVTVVTFEFSSTDPRVDSGKWPKYTVFRIGSLFVSGREKSVYLY
CRVNGTNKIQMKWGMEARRCLLQSMQQMEAIVEQESSIQGYDMTKACFKG
DRVNSPKTFSIGTQEGKLVKGSFGKALRVIFTKCLMHYVFGNAQLEGFSA
ESRRLLLLIQALKDRKGPWVFDLEGMYSGIEECISNNPWVIQSAYWFNEW
LGFEKEGSKVLESVDE
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5m3j Structural basis of an essential interaction between influenza polymerase and Pol II CTD.
Resolution3.5 Å
Binding residue
(original residue number in PDB)		K330 W364 A365 T366 G367 D368 G369 L370 T371 Y372 K392 P394 Q504 H506 V513 T515 R558 V559 N560 G561 Q566
Binding residue
(residue number reindexed from 1)		K324 W358 A359 T360 G361 D362 G363 L364 T365 Y366 K386 P388 Q498 H500 V507 T509 R552 V553 N554 G555 Q560
Enzymatic activity
Enzyme Commision number 3.1.-.-
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
GO:0039694 viral RNA genome replication
GO:0075526 cap snatching
Cellular Component
GO:0030430 host cell cytoplasm
GO:0042025 host cell nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5m3j, PDBe:5m3j, PDBj:5m3j
PDBsum5m3j
PubMed28002402
UniProtQ5V8Z9

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