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Receptor Information

>5m3h Chain A (length=699) Species: 11320 (Influenza A virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

MENFVRTNFNPMILERAEKTMKEYGENPQNEGNKFAAISTHMEVCFMYSD
FHFIDLEGNTIVKENDDDNAMLKHRFEIIEGQERNIAWTIVNSICNMTEN
SKPRFLPDLYDYKTNKFIEIGVTRRKVEDYYYEKASKLKGENVYIHIFSF
DGEEMATDDEYILDEESRARIKTRLFVLRQELATALEEEFSYPPTFQRLA
NQSLPPSFKDYHQFKAYVSSFKANGNIEAKLGAMSEKVNAQIESFDPRTI
RELELPEGKFCTQRSKFLLMDAMKLSVLNPAHEGEGIPMKDAKACLDTFW
GWKKATIIKKHEKGVNTNYLMIWEQLLESIKEMEGKFLNLKKTNHLKWGL
GEGQAPEKMDFEDCKEVPDLFQYKSEPPEKRKLASWIQSEFNKASELTNS
NWIEFDELGNDVAPIEHIASRRRNFFTAEVSQCRASEYIMKAVYINTALL
NSSCTAMEEYQVIPIITKCRDTSGQRRTNLYGFIIKGRSHLRNDTDVVNF
ISLEFSLTDPRNEIHKWEKYCVLEIGDMEIRTSISTIMKPVYLYVRTNGT
SKIKMKWGMEMRRCLLQSLQQVESMIEAESAVKEKDMTEPFFRNRENDWP
IGESPQGIEKGTIGKVCRVLLAKSVFNSIYASAQLEGFSAESRKLLLLIQ
AFRDNLDPGTFDLKGLYEAIEECIINDPWVLLNASWFNSFLKAVQLSMG

Receptor-Ligand Complex Structure

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Structure summary

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PDB	5m3h Structural basis of an essential interaction between influenza polymerase and Pol II CTD.
Resolution	2.5 Å
Binding residue (original residue number in PDB)	R279 K281 H326 K328 W363 G366 E367 G368 Q369 A370 P371 Y388 K389 S390 P392 P393 R503 H505 V512 N514 R561 T562 N563 G564 K569
Binding residue (residue number reindexed from 1)	R264 K266 H311 K313 W348 G351 E352 G353 Q354 A355 P356 Y373 K374 S375 P377 P378 R488 H490 V497 N499 R546 T547 N548 G549 K554

Enzyme Commision number

	Molecular Function
GO:0003723	RNA binding
GO:0046872	metal ion binding

	Biological Process
GO:0039694	viral RNA genome replication
GO:0075523	viral translational frameshifting

PDB	RCSB:5m3h, PDBe:5m3h, PDBj:5m3h
PDBsum	5m3h
PubMed	28002402
UniProt	H6QM92

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Structure of PDB 5m3h Chain A Binding Site BS02