Structure of PDB 5luz Chain A Binding Site BS02

Receptor Information

>5luz Chain A (length=662) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

SSYTVAGRNVLRWDLSPEQIKTRTEELIVQTKQVYDAVGMLGIEEVTYEN
CLQALADVEVKYIVERTMLDFPQHVSSDKEVRAASTEADKRLSRFDIEMS
MRGDIFERIVHLQETCDLGKIKPEARRYLEKSIKMGKRNGLHLPEQVQNE
IKSMKKRMSELCIDFNKNLNEDDTFLVFSKAELGALPDFIDSLEKTDDDK
YKITLKYPHYFPVMKKCCIPETRRRMEMAFNTRCKEENTIILQQLLPLRT
KVAKLLGYSTHADFVLEMNTAKSTSRVTAFLDDLSQKLKPLGEAEREFIL
NLKKKECKDRGFEYDGKINAWDLYYYMTQTEELKYSIDQEFLKEYFPIEV
VTEGLLNTYQELLGLSFEQMTDAHVWNKSVTLYTVKDKATGEVLGQFYLD
LYPREGKYNHAACFGLQPGCLLPDGSRMMAVAALVVNFSQPGRPSLLRHD
EVRTYFHQFGHVMHQICAQTDFARFSGTNVETDFVEVPSQMLENWVWDVD
SLRRLSKHYKDGSPIADDLLEKLVASRLVNTGLLTLRQIVLSKVDQSLHT
NTSLDAASEYAKYCSEILGVAATPGTNMPATFGHLAGGYDGQYYGYLWSE
VFSMDMFYSCFKKEGIMNPEVGMKYRNLILKPGGSLDGMDMLHNFLKREP
NQKAFLMSRGLH

Ligand information

>5luz Chain P (length=3) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

YIL

Receptor-Ligand Complex Structure

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Structure summary

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PDB	5luz Mechanism of Peptide Binding and Cleavage by the Human Mitochondrial Peptidase Neurolysin.
Resolution	2.7 Å
Binding residue (original residue number in PDB)	Y339 R554 Q555 H601 Y610 Y613
Binding residue (residue number reindexed from 1)	Y324 R537 Q538 H584 Y593 Y596

Enzymatic activity

Enzyme Commision number

3.4.24.16: neurolysin.

Gene Ontology

	Molecular Function
GO:0004222	metalloendopeptidase activity
GO:0008233	peptidase activity
GO:0008237	metallopeptidase activity
GO:0042277	peptide binding
GO:0046872	metal ion binding

	Biological Process
GO:0006111	regulation of gluconeogenesis
GO:0006508	proteolysis
GO:0006518	peptide metabolic process
GO:0007186	G protein-coupled receptor signaling pathway
GO:1902809	regulation of skeletal muscle fiber differentiation

	Cellular Component
GO:0005576	extracellular region
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005758	mitochondrial intermembrane space
GO:0005829	cytosol
GO:0005886	plasma membrane

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:5luz, PDBe:5luz, PDBj:5luz
PDBsum	5luz
PubMed	29183787
UniProt	Q9BYT8\|NEUL_HUMAN Neurolysin, mitochondrial (Gene Name=NLN)

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