Structure of PDB 5lsw Chain A Binding Site BS02

Receptor Information
>5lsw Chain A (length=273) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GPHMLEREKIYQWINELSSPETRENALLELSKKRESVPDLAPMLWHSFGT
IAALLQEIVNIYPSINPPTLTAHQSNRVCNALALLQCVASHPETRSAFLA
AHIPLFLYPFLHTVSKTRPFEYLRLTSLGVIGALVKTDEQEVINFLLTTE
IIPLCLRIMESGSELSKTVATFILQKILLDDTGLAYICQTYERFSHVAMI
LGKMVLQLSKEPSARLLKHVVRCYLRLSDNPRAREALRQCLPDQLKDTTF
AQVLKDDTTTKRWLAQLVKNLQE
Ligand information
>5lsw Chain D (length=21) Species: 7227 (Drosophila melanogaster) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
EGGIDSGMMLQLEKNLVDIVD
Receptor-Ligand Complex Structure
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PDB5lsw A CAF40-binding motif facilitates recruitment of the CCR4-NOT complex to mRNAs targeted by Drosophila Roquin.
Resolution2.15 Å
Binding residue
(original residue number in PDB)		R274 Q278
Binding residue
(residue number reindexed from 1)		R262 Q266
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0006402 mRNA catabolic process
Cellular Component
GO:0030014 CCR4-NOT complex

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Biological Process
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Cellular Component
External links
PDB RCSB:5lsw, PDBe:5lsw, PDBj:5lsw
PDBsum5lsw
PubMed28165457
UniProtQ92600|CNOT9_HUMAN CCR4-NOT transcription complex subunit 9 (Gene Name=CNOT9)

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