Structure of PDB 5lrm Chain A Binding Site BS02

Receptor Information
>5lrm Chain A (length=312) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TIYHAKDAVQATKPDMRKPRLVVFVVGETARADHVSFNGYERDTFPQLAK
IDGVTNFSNVTSCGTSTAYSVPCMFSYLGADEYDVDTAKYQENVLDTLDR
LGVSILWRDNNSDSKGVMDKLPKAQFADYKSATNNAICNTNPYNECRDVG
MLVGLDDFVAANNGKDMLIMLHQMGNHGPAYFKRYDEKFAKFTPVQSLIN
AYDNALLATDDFIAQSIQWLQTHSNAYDVSMLYVSDHGESLGENGVYLHG
MPNAFAPKEQRSVPAFFWTDKQTGITPMATDTVLTHDAITPTLLKLFDVT
ADKVKDRTAFIR
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain5lrm Chain A Residue 602 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5lrm Insights into the Mechanistic Basis of Plasmid-Mediated Colistin Resistance from Crystal Structures of the Catalytic Domain of MCR-1.
Resolution1.75 Å
Binding residue
(original residue number in PDB)		H395 H478
Binding residue
(residue number reindexed from 1)		H177 H249
Annotation score4
Enzymatic activity
Enzyme Commision number 2.7.-.-
Gene Ontology
Molecular Function
GO:0016772 transferase activity, transferring phosphorus-containing groups

View graph for
Molecular Function
External links
PDB RCSB:5lrm, PDBe:5lrm, PDBj:5lrm
PDBsum5lrm
PubMed28059088
UniProtA0A0R6L508|MCR1_ECOLX Probable phosphatidylethanolamine transferase Mcr-1 (Gene Name=mcr1)

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