Structure of PDB 5lpv Chain A Binding Site BS02

Receptor Information

>5lpv Chain A (length=285) Species: 3702 (Arabidopsis thaliana)

PLRKLAFADLLQATNGFHNDSLIGSGGFGDVYKAILKDGSAVAIKKLIHV
SGQGDREFMAEMETIGKIKHRNLVPLLGYCKVGDERLLVYEFMKYGSLED
VLHDGVKLNWSTRRKIAIGSARGLAFLHHNCSPHIIHRDMKSSNVLLDEN
LEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEYYQSFRCSTKGDVY
SYGVVLLELLTGKRPTDSPNLVGWVKQHAKLRISDVFDPELMKEDPALEI
ELLQHLKVAVACLDDRAWRRPTMVQVMAMFKEIQA

Ligand information

• Ligand ID: MN
• InChI: InChI=1S/Mn/q+2
• InChIKey: WAEMQWOKJMHJLA-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mn+2]
  CACTVS 3.341: [Mn++]
• Formula: Mn
• Name: MANGANESE (II) ION
• DrugBank: DB06757
• PDB chain: 5lpv Chain A Residue 1201

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5lpv Crystal structures of the phosphorylated BRI1 kinase domain and implications for brassinosteroid signal initiation.
• Resolution: 2.7 Å
• Binding residue (original residue number in PDB): N1014 D1027
• Binding residue (residue number reindexed from 1): N144 D157
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): D1009 K1011 S1013 N1014 D1027 M1037 T1049
• Catalytic site (residue number reindexed from 1): D139 K141 S143 N144 D157 M167 T179
• Enzyme Commision number: 2.7.10.1: receptor protein-tyrosine kinase.
  2.7.11.1: non-specific serine/threonine protein kinase.

Gene Ontology

Molecular Function

• GO:0004672 protein kinase activity
• GO:0005524 ATP binding

Biological Process

• GO:0006468 protein phosphorylation

External links

• PDB: RCSB:5lpv, PDBe:5lpv, PDBj:5lpv
• PDBsum: 5lpv
• UniProt: O22476|BRI1_ARATH Protein BRASSINOSTEROID INSENSITIVE 1 (Gene Name=BRI1)