Structure of PDB 5las Chain A Binding Site BS02

Receptor Information
>5las Chain A (length=215) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PALKLALEYIVPAMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTDG
QLVSQKSDSSKDIRGDKITWIEGKEPGCETIGLLMSSMDDLICHCNGKLG
SYKINGRTKAMVACYPGNGTGYVRHVDNCNGDGRCVTCIYYLNKDWDAKV
SGGILRIFPEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATRYAITV
WYFDADETAAAKVKY
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5las Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases.
Resolution2.1 Å
Binding residue
(original residue number in PDB)		S245 S247 D250
Binding residue
(residue number reindexed from 1)		S57 S59 D62
Enzymatic activity
Enzyme Commision number 1.14.11.29: hypoxia-inducible factor-proline dioxygenase.
Gene Ontology
Molecular Function
GO:0005506 iron ion binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0031418 L-ascorbic acid binding

View graph for
Molecular Function
External links
PDB RCSB:5las, PDBe:5las, PDBj:5las
PDBsum5las
PubMed27561929
UniProtQ9GZT9|EGLN1_HUMAN Egl nine homolog 1 (Gene Name=EGLN1)

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