Structure of PDB 5la9 Chain A Binding Site BS02

Receptor Information
>5la9 Chain A (length=205) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LPALKLALEYIVPAMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTD
GQLVIRGDKITWIEGKEPGCETIGLLMSSMDDLICHCNGKLGSYKINGRT
KAMVACYPGNGTGYVRHCDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIF
PEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADER
AAAKV
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5la9 Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases.
Resolution2.813 Å
Binding residue
(original residue number in PDB)		N306 G307 P378
Binding residue
(residue number reindexed from 1)		N110 G111 P182
Enzymatic activity
Enzyme Commision number 1.14.11.29: hypoxia-inducible factor-proline dioxygenase.
Gene Ontology
Molecular Function
GO:0005506 iron ion binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0031418 L-ascorbic acid binding

View graph for
Molecular Function
External links
PDB RCSB:5la9, PDBe:5la9, PDBj:5la9
PDBsum5la9
PubMed27561929
UniProtQ9GZT9|EGLN1_HUMAN Egl nine homolog 1 (Gene Name=EGLN1)

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