Structure of PDB 5l9b Chain A Binding Site BS02

Receptor Information
>5l9b Chain A (length=222) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LPALKLALEYIVPAMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTD
GQLVSQKSDSSKDIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCNGKL
GSYKINGRTKAMVACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAK
VSGGILRIFPEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATRYAIT
VWYFDADERAAAKVKYLTGEKG
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5l9b Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases.
Resolution1.95 Å
Binding residue
(original residue number in PDB)		K337 V338
Binding residue
(residue number reindexed from 1)		K150 V151
Enzymatic activity
Enzyme Commision number 1.14.11.29: hypoxia-inducible factor-proline dioxygenase.
Gene Ontology
Molecular Function
GO:0005506 iron ion binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0031418 L-ascorbic acid binding

View graph for
Molecular Function
External links
PDB RCSB:5l9b, PDBe:5l9b, PDBj:5l9b
PDBsum5l9b
PubMed27561929
UniProtQ9GZT9|EGLN1_HUMAN Egl nine homolog 1 (Gene Name=EGLN1)

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