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BioLiP

Structure of PDB 5kt4 Chain A Binding Site BS02

Receptor Information
>5kt4 Chain A (length=378) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SSRVIVHVDLDCFYAQVEMISNPELKDKPLGVQQKYLVVTCNYEAGKLGV
KKLMNVRDAKEKCPQLVLVNGEDLTRYREMSYKVTELLEEFSPVVERLGF
DENFVDLTEMVEKRLQQLQSDELSAVTVSGHVYNNQSINLLDVLHIRLLV
GSQIAAEMREAMYNQLGLTGCAGVASNKLLAKLVSGVFKPNQQTVLLPES
CQHLIHSLNHIKEIPGIGYKTAKCLEALGINSVRDLQTFSPKILEKELGI
SVAQRIQKLSFGEDNSPVILSGPPQSFSEEDSFKKCSSEVEAKNKIEELL
ASLLNRVCQDGRKPHTVRLIIRRYGRESRQCPIPSHVIQKLGYDVMTPMV
DILMKLFRNMVNVKFHLTLLSVCFCNLK
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5kt4 Kinetic and Structural Impact of Metal Ions and Genetic Variations on Human DNA Polymerase iota.
Resolution2.78 Å
Binding residue
(original residue number in PDB)		E152 K232 G266 I267 G268 T271 E383 S384 R385
Binding residue
(residue number reindexed from 1)		E102 K182 G216 I217 G218 T221 E327 S328 R329
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003684 damaged DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:5kt4, PDBe:5kt4, PDBj:5kt4
PDBsum5kt4
PubMed27555320
UniProtQ9UNA4|POLI_HUMAN DNA polymerase iota (Gene Name=POLI)

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