Structure of PDB 5koe Chain A Binding Site BS02

Receptor Information
>5koe Chain A (length=446) Species: 3702 (Arabidopsis thaliana) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DKLLGGLLASGFDEDSCLSRYQSVHYRKPSPYKPSSYLISKLRNYEKLHK
RCGPGTESYKKALKQLDQDGDGECKYVVWISFSGLGNRILSLASVFLYAL
LTDRVLLVDRGKDMDDLFCEPFLGMSWLLPLDFPMTDQFDGLNQESSRCY
GYMVKNQVIDLSHLYLHLVHDYGDHDKMFFCEGDQTFIGKVPWLIVKTDN
YFVPSLWLIPGFDDELNKLFPQKATVFHHLGRYLFHPTNQVWGLVTRYYE
AYLSHADEKIGIQVRVFDEDPGPFQHVMDQISSCTQKEKLLPEVDTLVEN
TPKHKAVLVTSLNAGYAENLKSMYWEYPTSTGEIIGVHQPSQEGYMHNGK
ALAEMYLLSLTDNLVTSAWSTFGYVAQGLGGLKPWILYRPENRTTPDPSC
GRAMSMEPCFHSPPFYDCKAKTGIDTGTLVPHVRHCEDISWGLKLV
Ligand information
Ligand IDGAL
InChIInChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3+,4+,5-,6-/m1/s1
InChIKeyWQZGKKKJIJFFOK-FPRJBGLDSA-N
SMILES
SoftwareSMILES
CACTVS 3.370OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@H]1O
OpenEye OEToolkits 1.7.2C(C1C(C(C(C(O1)O)O)O)O)O
CACTVS 3.370OC[CH]1O[CH](O)[CH](O)[CH](O)[CH]1O
ACDLabs 12.01OC1C(O)C(OC(O)C1O)CO
OpenEye OEToolkits 1.7.2C([C@@H]1[C@@H]([C@@H]([C@H]([C@@H](O1)O)O)O)O)O
FormulaC6 H12 O6
Namebeta-D-galactopyranose;
beta-D-galactose;
D-galactose;
galactose
ChEMBLCHEMBL300520
DrugBank
ZINCZINC000002597049
PDB chain5koe Chain E Residue 8 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5koe Structural, mutagenic and in silico studies of xyloglucan fucosylation in Arabidopsis thaliana suggest a water-mediated mechanism.
Resolution1.79 Å
Binding residue
(original residue number in PDB)		N184 H271 N301 H523 S524
Binding residue
(residue number reindexed from 1)		N87 H170 N200 H411 S412
Annotation score1
Enzymatic activity
Enzyme Commision number 2.4.1.-
Gene Ontology
Molecular Function
GO:0008107 galactoside 2-alpha-L-fucosyltransferase activity
Biological Process
GO:0042546 cell wall biogenesis
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5koe, PDBe:5koe, PDBj:5koe
PDBsum5koe
PubMed28670741
UniProtQ9SWH5|FUT1_ARATH Galactoside 2-alpha-L-fucosyltransferase (Gene Name=FUT1)

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