Structure of PDB 5kg6 Chain A Binding Site BS02

Receptor Information
>5kg6 Chain A (length=431) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GPHMATGQDRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGI
IAVSYEARAFGVTRSMWADDAKKLCPDLLLAQVRESRGKANLTKYREASV
EVMEIMSRFAVIERASIDEAYVDLTSAVQERLQKLQGQPISADLLPSTYI
EGLPQGPETVQKEGMRKQGLFQWLDSLQIDNLTSPDLQLTVGAVIVEEMR
AAIERETGFQCSAGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQMP
IRKIRSLGGKLGASVIEILGIEYMGELTQFTESQLQSHFGEKNGSWLYAM
CRGIEHDPVKPRQLPKTIGCSKNFPGKTALATREQVQWWLLQLAQELEER
LTKDRNDNDRVATQLVVSIRVQGDKRLSSLRRCCALTRYDAHKMSHDAFT
VIKNCNTSGIQTEWSPPLTMLFLCATKFSAS
Ligand information
Receptor-Ligand Complex Structure
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PDB5kg6 Capture of a third Mg2+ is essential for catalyzing DNA synthesis.
Resolution1.55 Å
Binding residue
(original residue number in PDB)		F18 R61 S113 D115 E116 S257 G259 G260 K261 L262 R377 R382 C384
Binding residue
(residue number reindexed from 1)		F21 R64 S116 D118 E119 S256 G258 G259 K260 L261 R376 R381 C383
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003684 damaged DNA binding
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:5kg6, PDBe:5kg6, PDBj:5kg6
PDBsum5kg6
PubMed27284197
UniProtQ9Y253|POLH_HUMAN DNA polymerase eta (Gene Name=POLH)

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