Structure of PDB 5jhq Chain A Binding Site BS02

Receptor Information

>5jhq Chain A (length=462) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

GALRELLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKD
VVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDN
WNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVL
TGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYN
RVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNA
MDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPEL
RERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAV
ASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKH
GAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQM
GNEAVQQILSES

Ligand information

>5jhq Chain F (length=11) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

GYRQSPDGACS

Receptor-Ligand Complex Structure

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Structure summary

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PDB	5jhq Tankyrase-1 Ankyrin Repeats Form an Adaptable Binding Platform for Targets of ADP-Ribose Modification.
Resolution	3.2 Å
Binding residue (original residue number in PDB)	R368 S370 L375 G378 Y379 N408 Y412 H414 D432 W434 F436 E441 R447
Binding residue (residue number reindexed from 1)	R188 S190 L195 G198 Y199 N228 Y232 H234 D252 W254 F256 E261 R267

Enzymatic activity

Enzyme Commision number

2.4.2.-
2.4.2.30: NAD(+) ADP-ribosyltransferase.

External links

PDB	RCSB:5jhq, PDBe:5jhq, PDBj:5jhq
PDBsum	5jhq
PubMed	27594684
UniProt	O95271\|TNKS1_HUMAN Poly [ADP-ribose] polymerase tankyrase-1 (Gene Name=TNKS)

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