Structure of PDB 5jbj Chain A Binding Site BS02

Receptor Information

>5jbj Chain A (length=627) Species: 9031 (Gallus gallus)

SELHGYQLEAVAPALRGRNSIVWLPTGAGKTRAAVHVCRRHLEGRRGGRV
AVLVNKVHLVQQHLEKEFHVLRDAFKVTAVSGDSSHKCFFGQLAKGSDVV
ICTAQILQNALLSGEEEARVELTDFSLLVIDECHHTQKEAVYNKIMLSYL
QKKLSGQRDLPQILGLTASPGTGGETSFEGAVEHILQICANLDTEVIASA
REQDPFGQRLKKIMAQIQEHMEMPELPQNFGTQVYEQRIVELENRAAERF
CRKTRVCALHLRRYNDALLINDTVRMMDAFQCLQQFYADKDPTERFLATT
FEENRATLQALAGDQRYNPRLSKLEEILQEHFQPPGSSRGIVFTKTRQSA
HSLLSWLQDTAGLCGQHIRAAVLTGSGHSNQAKGMTQNEQQDVITLFRYG
ELNLLFSTSVAEEGLDIPECNIVVRYGLMTNEIAMVQAQGRARAQNSMYS
VLAKANLMERAIRAVQAMPERKYRLKIVELQRNAVLSWQVKEARSSERRQ
LHDPDDVYFHCVNCNVAVCRGSDIRTVEAMHHVNINPNFRFYYTVSSGKI
HFERTFRDWEPGCRIVCSECRQEWGMEMIYRNVTLPILSIKNFVVVTPDE
KKKYKKWSTVTFPIEEFSYLEYCSSTQ

Ligand information

>5jbj Chain Y (length=12)

gguagcgcuacc

............

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5jbj Structural Analysis of dsRNA Binding to Anti-viral Pattern Recognition Receptors LGP2 and MDA5.
• Resolution: 3.58 Å
• Binding residue (original residue number in PDB): N55 K56 V57 G82 S85 T103 Q105 N109 Q260 R285 K373 T374 R375 T402 G403 Q409 Q415 T436 V438 E571 M573 H574 R597 F599 W602 K648
• Binding residue (residue number reindexed from 1): N55 K56 V57 G82 S85 T103 Q105 N109 Q237 R262 K345 T346 R347 T374 G375 Q381 Q387 T408 V410 E528 M530 H531 R554 F556 W559 K605

Enzymatic activity

• Enzyme Commision number: 3.6.4.13: RNA helicase.

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0003723 RNA binding
• GO:0003724 RNA helicase activity
• GO:0004386 helicase activity
• GO:0005524 ATP binding
• GO:0016787 hydrolase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0045087 innate immune response

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:5jbj, PDBe:5jbj, PDBj:5jbj
• PDBsum: 5jbj
• PubMed: 27203181
• UniProt: G0YYQ5