Structure of PDB 5jax Chain A Binding Site BS02

Receptor Information
>5jax Chain A (length=130) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IKHTEYMEFLKSVPTFQSLPEEILSKLADVLEETHYENGEYIIRQGARGD
TFFIISKGTVNVTREDSPSEDPVFLRTLGKGDWFGEKALQGEDVRTANVI
AAEAVTCLVIDRDSFKHLIGGLDDVSNKAY
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain5jax Chain A Residue 402 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5jax Structural Basis of Analog Specificity in PKG I and II.
Resolution1.486 Å
Binding residue
(original residue number in PDB)		G342 D344
Binding residue
(residue number reindexed from 1)		G121 D123
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.11.12: cGMP-dependent protein kinase.
Gene Ontology
Molecular Function
GO:0004692 cGMP-dependent protein kinase activity
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:5jax, PDBe:5jax, PDBj:5jax
PDBsum5jax
PubMed28793191
UniProtQ13976|KGP1_HUMAN cGMP-dependent protein kinase 1 (Gene Name=PRKG1)

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