Structure of PDB 5iud Chain A Binding Site BS02

Receptor Information
>5iud Chain A (length=859) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EQVFHFYWLDAYEDQYNQPGVVFLFGKVWIESAETHVSCCVMVKNIERTL
YFLPREMKIDLNTGKETGTPISMKDVYEEFDEKIATKYKIMKFKSKPVEK
NYAFEIPDVPEKSEYLEVKYSAEMPQLPQDLKGETFSHVFGTNTSSLELF
LMNRKIKGPCWLEVKSPQLLNQPVSWCKVEAMALKPDLVNVIKDVSPPPL
VVMAFSMKTMQNAKNHQNEIIAMAALVHHSFALDKAAPKPPFQSHFCVVS
KPKDCIFPYAFKEVIEKKNVKVEVAATERTLLGFFLAKVHKIDPDIIVGH
NIYGFELEVLLQRINVCKAPHWSKIGRLKRSNMPKLGERNATCGRMICDV
EISAKELIRCKSYHLSELVQQILKTERVVIPMENIQNMYSESSQLLYLLE
HTWKDAKFILQIMCELNVLPLALQITNIAGNIMSRTLMGGRSERNEFLLL
HAFYENNYIVPDKQIKAAYAGGLVLDPKVGFYDKFILLLDFNSLYPSIIQ
EFNICFTTVQRIPELPDPSLEMGILPREIRKLVERRKQVKQLMKQQDLNP
DLILQYDIRQKALKLTANSMYGCLGFSYSRFYAKPLAALVTYKGREILMH
TKEMVQKMNLEVIYGDTDSIMINTNSTNLEEVFKLGNKVKSEVNKLYKLL
EIDIDGVFKSLLLLKKKKYAALVVEPTSDGNYVTKQELKGLDIVRRDWCD
LAKDTGNFVIGQILSDQSRDTIVENIQKRLIEIGENVLNGSVPVSQFEIN
KALTKDPQDYPDKKSLPHVHVALWINSQGGRKVKAGDTVSYVICQDGSNL
TASQRAYAPEQLQKQDNLTIDTQYYLAQQIHPVVARICEPIDGIDAVLIA
TWLGLDPTQ
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5iud Human DNA polymerase alpha in binary complex with a DNA:DNA template-primer.
Resolution3.3 Å
Binding residue
(original residue number in PDB)		R702 D1002 K1053 K1075 G1076 R1081 R1082 K1137 A1138 T1140 Y1146 H1154
Binding residue
(residue number reindexed from 1)		R359 D616 K667 K689 G690 R695 R696 K751 A752 T754 Y760 H768
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:1902975 mitotic DNA replication initiation

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Molecular Function
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Biological Process
External links
PDB RCSB:5iud, PDBe:5iud, PDBj:5iud
PDBsum5iud
PubMed27032819
UniProtP09884|DPOLA_HUMAN DNA polymerase alpha catalytic subunit (Gene Name=POLA1)

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