Structure of PDB 5ino Chain A Binding Site BS02

Receptor Information

>5ino Chain A (length=253) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

QENGSMFSLITWNIDGLDLNNLSERARGVCSYLALYSPDVIFLQEVIPPY
YSYLKKRSSNYEIITGHEEGYFTAIMLKKSRVKLKSQEIIPFPSTKMMRN
LLCVHVNVSGNELCLMTSHLESTRGHAAERMNQLKMVLKKMQEAPESATV
IFAGDTNLRDREVTRCGGLPNNIVDVWEFLGKPKHCQYTWDTQMNSNLGI
TAACKLRFDRIFFRAAAEGHIIPRSLDLLGLEKLDCGRFPSDHWGLLCNL
DII

Ligand information

>5ino Chain C (length=9) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

ccgaattcg

Receptor-Ligand Complex Structure

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Structure summary

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PDB	5ino Reversal of DNA damage induced Topoisomerase 2 DNA-protein crosslinks by Tdp2.
Resolution	3.205 Å
Binding residue (original residue number in PDB)	G306 I307 T308
Binding residue (residue number reindexed from 1)	G199 I200 T201

Enzymatic activity

Enzyme Commision number

3.1.4.-

Gene Ontology

	Molecular Function
GO:0003824	catalytic activity

View graph for
Molecular Function

External links

PDB	RCSB:5ino, PDBe:5ino, PDBj:5ino
PDBsum	5ino
PubMed	27060144
UniProt	O95551\|TYDP2_HUMAN Tyrosyl-DNA phosphodiesterase 2 (Gene Name=TDP2)

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