Structure of PDB 5imt Chain A Binding Site BS02

Receptor Information

>5imt Chain A (length=460) Species: 1338 (Streptococcus intermedius)

NSEAAKKALNDYIWGLQYDKLNILTHQGEKLKNHSSREAFHRPGEYVVIE
KKKQSISNATSKLSVSSANDDRIFPGALLKADQSLLENLPTLIPVNRGKT
TISVNLPGLKNGESNLTVENPSNSTVRTAVNNLVEKWIQNYSKTHAVPAR
MQYESISAQSMSQLQAKFGADFSKVGAPLNVDFSSVHKGEKQVFIANFRQ
VYYTASVDSPNSPSALFGSGITPTDLINRGVNSKTPPVYVSNVSYGRAMY
VKFETTSKSTKVQAAIDAVVKILKNTKICAVVLGGNPGEASKVCTGNIDT
LKDLIQKGSNFSAQSPAVPISYTTSFVKDNSIATIQNNTDYIETKVTSYK
DGALTLNHDGAFVARFYVYWEELGHDAEGYETIRSRSWSGNGYNRGAHYS
TTLRFKGNVRNIRVKVLGATGLAWEPWRLIYSKNDLPLVPQRNISTWGTT
LHPQFEDKVV

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 5imt Chain A Residue 607

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5imt Structural Basis for Receptor Recognition by the Human CD59-Responsive Cholesterol-Dependent Cytolysins.
• Resolution: 2.7001 Å
• Binding residue (original residue number in PDB): H442 E448
• Binding residue (residue number reindexed from 1): H375 E381
• Annotation score: 4

Gene Ontology

Molecular Function

• GO:0008289 lipid binding
• GO:0015485 cholesterol binding
• GO:0046872 metal ion binding
• GO:0090729 toxin activity

Biological Process

• GO:0031640 killing of cells of another organism
• GO:0035821 modulation of process of another organism

Cellular Component

• GO:0005576 extracellular region
• GO:0016020 membrane
• GO:0020002 host cell plasma membrane

External links

• PDB: RCSB:5imt, PDBe:5imt, PDBj:5imt
• PDBsum: 5imt
• PubMed: 27499440
• UniProt: Q9LCB8