Structure of PDB 5ikk Chain A Binding Site BS02

Receptor Information
>5ikk Chain A (length=594) Species: 284812 (Schizosaccharomyces pombe 972h-) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LKKSGLCYDPRMRFHATLSEHPEDPRRVLRVFEAIKKAGYVSNVPSPSDV
FLRIPAREATLEELLQVHSQEMYDKMSHEDLANLEKISDSLYYNNESAFC
ARLACGSAIETCTAVVTGQVKNAFAVVRPPGHHALFNNVSVTARSMLQRF
PDKIKRVLIVDWDIHHGNGTQMAFYDDPNVLYVSLHRYENGRFYPGTNYG
CAENCGEGPGLGRTVNIPWSCAGMGDGDYIYAFQRVVMPVAYEFDPDLVI
VSCGFDAAAGDHIGQFLLTPAAYAHMTQMLMGLADGKVFISLEGGYNLDS
ISTSALAVAQSLLGIPPGRLHTTYACPQAVATINHVTKIQSQYWRCMRPK
HFDANPKDAHVDRLHDVIRTYQAKKLFEDWKITNMPILRDNNQVLCSSNF
FQKDNLLVIVHESPRVLGNGTSETNVLNLNDSLLVDPVSLYVEWAMQQDW
GLIDINIPEVDILSEVKELCLYVWDNYVELSISKNIFFIGGGKAVHGLVN
LASSRNVSDRVKCMVNFLGTEPLVGLKTASEEDLPTWYYRHSLVFVSSSN
ECWKKAKRAKRRYGRLMQSEHTETSDMMEQHYRAVTQYLLHLLQ
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain5ikk Chain A Residue 703 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB5ikk SHREC Silences Heterochromatin via Distinct Remodeling and Deacetylation Modules.
Resolution2.4 Å
Binding residue
(original residue number in PDB)		H68 H77 C162
Binding residue
(residue number reindexed from 1)		H15 H21 C100
Annotation score1
Enzymatic activity
Enzyme Commision number 3.5.1.98: histone deacetylase.
Gene Ontology
Molecular Function
GO:0004407 histone deacetylase activity
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0031078 histone H3K14 deacetylase activity
Biological Process
GO:0000183 rDNA heterochromatin formation
GO:0006325 chromatin organization
GO:0010468 regulation of gene expression
GO:0030466 silent mating-type cassette heterochromatin formation
GO:0031508 pericentric heterochromatin formation
GO:0031509 subtelomeric heterochromatin formation
GO:0040029 epigenetic regulation of gene expression
GO:1902794 siRNA-independent facultative heterochromatin formation
Cellular Component
GO:0000118 histone deacetylase complex
GO:0000775 chromosome, centromeric region
GO:0000781 chromosome, telomeric region
GO:0000785 chromatin
GO:0000791 euchromatin
GO:0005634 nucleus
GO:0005694 chromosome
GO:0005721 pericentric heterochromatin
GO:0005730 nucleolus
GO:0031934 mating-type region heterochromatin
GO:0033553 rDNA heterochromatin
GO:0070824 SHREC complex
GO:0140720 subtelomeric heterochromatin
GO:1990342 heterochromatin island

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5ikk, PDBe:5ikk, PDBj:5ikk
PDBsum5ikk
PubMed27105116
UniProtP56523|CLR3_SCHPO Histone deacetylase clr3 (Gene Name=clr3)

[Back to BioLiP]