Structure of PDB 5hxx Chain A Binding Site BS02

Receptor Information
>5hxx Chain A (length=424) Species: 196627 (Corynebacterium glutamicum ATCC 13032) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VSLQDFDAERIGLFHEDIKRKFDELKSKNLKLDLTRGKPSSEQLDFADEL
LALPGKGDFKAADGTDVRNYGGLDGIVDIRQIWADLLGVPVEQVLAGDAS
SLNIMFDVISWSYIFGNNDSVQPWSKEETVKWICPVPGYDRHFSITERFG
FEMISVPMNEDGPDMDAVEELVKNPQVKGMWVVPVFSNPTGFTVTEDVAK
RLSAMETAAPDFRVVWDNAYAVHTLTDEFPEVIDIVGLGEAAGNPNRFWA
FTSTSKITLAGAGVSFFLTSAENRKWYTGHAGIRGIGPNKVNQLAHARYF
GDAEGVRAVMRKHAASLAPKFNKVLEILDSRLAEYGVAQWTVPAGGYFIS
LDVVPGTASRVAELAKEAGIALTGAGSSYPLRQDPENKNLRLAPSLPPVE
ELEVAMDGVATCVLLAAAEHYANH
Ligand information
Ligand IDAKG
InChIInChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)
InChIKeyKPGXRSRHYNQIFN-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04O=C(O)C(=O)CCC(=O)O
OpenEye OEToolkits 1.7.6C(CC(=O)O)C(=O)C(=O)O
CACTVS 3.385OC(=O)CCC(=O)C(O)=O
FormulaC5 H6 O5
Name2-OXOGLUTARIC ACID
ChEMBLCHEMBL1686
DrugBankDB08845
ZINCZINC000001532519
PDB chain5hxx Chain A Residue 502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5hxx Structural insights into a novel class of aspartate aminotransferase from Corynebacterium glutamicum
Resolution2.0 Å
Binding residue
(original residue number in PDB)		G40 Y142 R144 K259
Binding residue
(residue number reindexed from 1)		G37 Y139 R141 K256
Annotation score5
Enzymatic activity
Enzyme Commision number 2.6.1.1: aspartate transaminase.
Gene Ontology
Molecular Function
GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity
GO:0008483 transaminase activity

View graph for
Molecular Function
External links
PDB RCSB:5hxx, PDBe:5hxx, PDBj:5hxx
PDBsum5hxx
PubMed
UniProtQ8NTR2|ASPAT_CORGL Aspartate aminotransferase (Gene Name=Cgl0240)

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