Structure of PDB 5huc Chain A Binding Site BS02

Receptor Information
>5huc Chain A (length=449) Species: 1718 (Corynebacterium glutamicum) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DLPPLPEGMQQQFEDTISRDAKQQPTWDRAQAENVRKILESVPPIVVAPE
VLELKQKLADVANGKAFLLQGGDCAETFESNTEPHIRANVKTLLQMAVVL
TYGASTPVIKMARIAGQYAKPRSSDLDGNGLPNYRGDIVNGVEATPEARR
HDPARMIRAYANASAAMNLVRALTSSGTADLYRLSEWNREFVANSPAGAR
YEALAREIDSGLRFMEACGVSDESLRAADIYCSHEALLVDYERSMLRLAT
DEEGNEELYDLSAHQLWIGERTRGMDDFHVNFASMISNPIGIKIGPGITP
EEAVAYADKLDPNFEPGRLTIVARMGHDKVRSVLPGVIQAVEASGHKVIW
QSDPMHGNTFTASNGYKTRHFDKVIDEVQGFFEVHRALGTHPGGIHIEFT
GEDVTECLGGAEDITDVDLPGRYESACDPRLNTQQSLELAFLVAEMLRN
Ligand information
Ligand IDPEP
InChIInChI=1S/C3H5O6P/c1-2(3(4)5)9-10(6,7)8/h1H2,(H,4,5)(H2,6,7,8)
InChIKeyDTBNBXWJWCWCIK-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C=C(C(=O)O)OP(=O)(O)O
CACTVS 3.341OC(=O)C(=C)O[P](O)(O)=O
ACDLabs 10.04O=C(O)C(\OP(=O)(O)O)=C
FormulaC3 H5 O6 P
NamePHOSPHOENOLPYRUVATE
ChEMBLCHEMBL1235228
DrugBankDB01819
ZINCZINC000003870145
PDB chain5huc Chain A Residue 502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5huc Inter-Enzyme Allosteric Regulation of Chorismate Mutase in Corynebacterium glutamicum: Structural Basis of Feedback Activation by Trp.
Resolution2.45 Å
Binding residue
(original residue number in PDB)		R136 E258 W290 G292 E293 K316 R347 H379
Binding residue
(residue number reindexed from 1)		R113 E235 W267 G269 E270 K293 R324 H356
Annotation score5
Enzymatic activity
Enzyme Commision number 2.5.1.54: 3-deoxy-7-phosphoheptulonate synthase.
Gene Ontology
Molecular Function
GO:0003849 3-deoxy-7-phosphoheptulonate synthase activity
GO:0016740 transferase activity
GO:0046872 metal ion binding
Biological Process
GO:0008652 amino acid biosynthetic process
GO:0009073 aromatic amino acid family biosynthetic process
GO:0009423 chorismate biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:5huc, PDBe:5huc, PDBj:5huc
PDBsum5huc
PubMed29178787
UniProtQ8NNL5

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