Structure of PDB 5hp4 Chain A Binding Site BS02

Receptor Information
>5hp4 Chain A (length=272) Species: 10726 (Tequintavirus T5) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RNLMIVDGTNLGFRFKHNNSKKPFASSYVSTIQSLAKSYSARTTIVLGDK
GKSVFRLEHLPEYKGNRDEKYAQRTEEEKALDEQFFEYLKDAFELCKTTF
PTFTIRGVEADDMAAYIVKLIGHLYDHVWLISTDGKWDTLLTDKVSRFSF
TTRREYHLRDMYEHHNVDDVEQFISLKAIMGDLGDNIRGVEGIGAKRGYN
IIREFGNVLDIIDQLPLPGKQKYIQNLNASEELLFRNLILVDLPTYCVDA
IAAVGQDVLDKFTKDILEIAEQ
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain5hp4 Chain A Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5hp4 Direct observation of DNA threading in flap endonuclease complexes.
Resolution1.86 Å
Binding residue
(original residue number in PDB)		E128 D130
Binding residue
(residue number reindexed from 1)		E109 D111
Annotation score4
Enzymatic activity
Enzyme Commision number 3.1.11.-
3.1.11.3: exodeoxyribonuclease (lambda-induced).
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003824 catalytic activity
GO:0004519 endonuclease activity
GO:0004527 exonuclease activity
GO:0004529 DNA exonuclease activity
GO:0008409 5'-3' exonuclease activity
GO:0016788 hydrolase activity, acting on ester bonds
GO:0017108 5'-flap endonuclease activity
GO:0035312 5'-3' DNA exonuclease activity
GO:0046872 metal ion binding
GO:0048256 flap endonuclease activity
GO:0051908 double-stranded DNA 5'-3' DNA exonuclease activity
GO:1990238 double-stranded DNA endonuclease activity
Biological Process
GO:0006260 DNA replication
GO:0019086 late viral transcription
GO:0033567 DNA replication, Okazaki fragment processing
GO:0039693 viral DNA genome replication
Cellular Component
GO:0019034 viral replication complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5hp4, PDBe:5hp4, PDBj:5hp4
PDBsum5hp4
PubMed27273516
UniProtP06229|FEN_BPT5 Flap endonuclease (Gene Name=D15)

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