Structure of PDB 5hp3 Chain A Binding Site BS02

Receptor Information
>5hp3 Chain A (length=394) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RQPIPSEGLQLHLPQVLADAVSRLVLGKFGDLTDNFSSPHARRKVLAGVV
MTTGTDVKDAKVISVSTGTKCINGEYMSDRGLALNDCHAEIISRRSLLRF
LYTQLELYLNNKDDQKRSIFQKSERGGFRLKENVQFHLYISTSPCGDARI
FSPHEPILEEPADRHPNRKARGQLRTKIESGEGTIPVRSNASIQTWDGVL
QGERLLTMSCSDKIARWNVVGIQGSLLSIFVEPIYFSSIILGSLYHGDHL
SRAMYQRISNIEDLPPLYTLNKPLLSGISNAEARQPGKAPNFSVNWTVGD
SAIEVINATTGKDELGRASRLCKHALYCRWMRVHGKVPSHLLRSKITKPN
VYHESKLAAKEYQAAKARLFTAFIKAGLGAWVEKPTEQDQFSLT
Ligand information
>5hp3 Chain C (length=23) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gacugaacgaccaauguggggaa
.......................
Receptor-Ligand Complex Structure
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PDB5hp3 Structures of human ADAR2 bound to dsRNA reveal base-flipping mechanism and basis for site selectivity.
Resolution3.091 Å
Binding residue
(original residue number in PDB)		R348 I456 F457 H471 R474 R477 R481 G487 E488 P492 S495 R510 K594
Binding residue
(residue number reindexed from 1)		R42 I150 F151 H165 R168 R171 R175 G181 E182 P186 S189 R204 K288
Enzymatic activity
Enzyme Commision number 3.5.4.37: double-stranded RNA adenine deaminase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0004000 adenosine deaminase activity
Biological Process
GO:0006396 RNA processing

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Molecular Function
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Biological Process
External links
PDB RCSB:5hp3, PDBe:5hp3, PDBj:5hp3
PDBsum5hp3
PubMed27065196
UniProtP78563|RED1_HUMAN Double-stranded RNA-specific editase 1 (Gene Name=ADARB1)

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