Structure of PDB 5hp2 Chain A Binding Site BS02

Receptor Information
>5hp2 Chain A (length=396) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PSRQPIPSEGLQLHLPQVLADAVSRLVLGKFGDLTDNFSSPHARRKVLAG
VVMTTGTDVKDAKVISVSTGTKCINGEYMSDRGLALNDCHAEIISRRSLL
RFLYTQLELYLNNKDDQKRSIFQKSERGGFRLKENVQFHLYISTSPCGDA
RIFSPHEPILEEPADRHPNRKARGQLRTKIESGEGTIPVRSNASIQTWDG
VLQGERLLTMSCSDKIARWNVVGIQGSLLSIFVEPIYFSSIILGSLYHGD
HLSRAMYQRISNIEDLPPLYTLNKPLLSGISNAEARQPGKAPNFSVNWTV
GDSAIEVINATTGKDELGRASRLCKHALYCRWMRVHGKVPSHLLRSKITK
PNVYHESKLAAKEYQAAKARLFTAFIKAGLGAWVEKPTEQDQFSLT
Ligand information
>5hp2 Chain C (length=23) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gacugaacgacuaauguggggaa
.......................
Receptor-Ligand Complex Structure
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PDB5hp2 Structures of human ADAR2 bound to dsRNA reveal base-flipping mechanism and basis for site selectivity.
Resolution2.983 Å
Binding residue
(original residue number in PDB)		R348 I456 F457 H471 R474 R477 R481 G487 E488 P492 R510 G593 K594
Binding residue
(residue number reindexed from 1)		R44 I152 F153 H167 R170 R173 R177 G183 E184 P188 R206 G289 K290
Enzymatic activity
Enzyme Commision number 3.5.4.37: double-stranded RNA adenine deaminase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0004000 adenosine deaminase activity
Biological Process
GO:0006396 RNA processing

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Molecular Function
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Biological Process
External links
PDB RCSB:5hp2, PDBe:5hp2, PDBj:5hp2
PDBsum5hp2
PubMed27065196
UniProtP78563|RED1_HUMAN Double-stranded RNA-specific editase 1 (Gene Name=ADARB1)

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