Structure of PDB 5hjm Chain A Binding Site BS02

Receptor Information
>5hjm Chain A (length=349) Species: 272844 (Pyrococcus abyssi GE5) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SHHHHHHLEVLFQGPHMSGVKVRREDAKKVLELLKSVGILDGKRKAIRDE
KYVIFPVTDTNIAKSLGLEVVDVELPMRPERQIYKNLEDLLPREIFKKLG
RLDIVGDIAIVSIPDEILSEREVIVSAIRKLYPKVKVIARRGFHSGLYRI
RELEVIWGENRLHTIHKENGVLIKVDLSKVFFNPRMKGERYRIAQLVNDG
ERILVPFAGVIPYPLVIARFKNVEVYAVEINEFAVKLAEENLELNRDRLK
GKIKIIHGDVFEVLPNLPNFDRVVSPTPKGVDALSLTLSKAEKFLHYYDF
VHESEIERFRERVLEECRRQGKECRVSVRKVSDYKPHVYKVCADVEILS
Ligand information
Ligand IDHSL
InChIInChI=1S/C4H7NO2/c5-3-1-2-7-4(3)6/h3H,1-2,5H2/t3-/m0/s1
InChIKeyQJPWUUJVYOJNMH-VKHMYHEASA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C1COC(=O)C1N
OpenEye OEToolkits 1.5.0C1COC(=O)[C@H]1N
ACDLabs 10.04O=C1OCCC1N
CACTVS 3.341N[C@H]1CCOC1=O
CACTVS 3.341N[CH]1CCOC1=O
FormulaC4 H7 N O2
NameHOMOSERINE LACTONE
ChEMBLCHEMBL1233424
DrugBank
ZINCZINC000034689286
PDB chain5hjm Chain A Residue 403 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5hjm Crystal structures of the bifunctional tRNA methyltransferase Trm5a
Resolution1.762 Å
Binding residue
(original residue number in PDB)		D266 Y281 D283 F293
Binding residue
(residue number reindexed from 1)		D282 Y297 D299 F309
Annotation score1
Enzymatic activity
Enzyme Commision number 2.1.1.-
2.1.1.228: tRNA (guanine(37)-N(1))-methyltransferase.
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity
GO:0008175 tRNA methyltransferase activity
GO:0016740 transferase activity
GO:0052906 tRNA (guanine(37)-N1)-methyltransferase activity
Biological Process
GO:0002939 tRNA N1-guanine methylation
GO:0008033 tRNA processing
GO:0030488 tRNA methylation
GO:0032259 methylation
Cellular Component
GO:0005737 cytoplasm

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Biological Process
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Cellular Component
External links
PDB RCSB:5hjm, PDBe:5hjm, PDBj:5hjm
PDBsum5hjm
PubMed27629654
UniProtQ9V2G1|TAW22_PYRAB tRNA (guanine(37)-N1)/4-demethylwyosine(37)-methyltransferase Taw22 (Gene Name=taw22)

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