Structure of PDB 5h6o Chain A Binding Site BS02

Receptor Information
>5h6o Chain A (length=281) Species: 666 (Vibrio cholerae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TPIRIATRQSPLALWQANYVKDALMAAHPGLQVELVTMVFVKELEIAMLE
GRADLAVHSMKDVPVDFPDGLGLVTICEREDPRDAFVSNTYAKIEDLPSG
AIVGTCSLRRQCQLKAARPDLVIKELRGNVGTRLSKLDAGEYDAIILAAA
GLKRLELESRIRSFIEPEQSLPAVGQGAVGIECRVNDQRVRALLAPLNHA
DTADRVRCERAMNLTLQGGCQVPIGSYALLEGDTIWLRALVGEPDGSQIV
RGEIRGPRTQAEQLGITLAEQLLSQGAKEIL
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain5h6o Chain A Residue 402 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5h6o Porphobilinogen deaminase from Vibrio Cholerae
Resolution2.702 Å
Binding residue
(original residue number in PDB)		L21 V158
Binding residue
(residue number reindexed from 1)		L12 V130
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) K89 D90 R137 R138 R155 R161 C248
Catalytic site (residue number reindexed from 1) K61 D62 R109 R110 R127 R133 C220
Enzyme Commision number 2.5.1.61: hydroxymethylbilane synthase.
Gene Ontology
Molecular Function
GO:0004418 hydroxymethylbilane synthase activity
GO:0016740 transferase activity
Biological Process
GO:0006779 porphyrin-containing compound biosynthetic process
GO:0006782 protoporphyrinogen IX biosynthetic process
GO:0006783 heme biosynthetic process
GO:0018160 peptidyl-pyrromethane cofactor linkage
GO:0033014 tetrapyrrole biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5h6o, PDBe:5h6o, PDBj:5h6o
PDBsum5h6o
PubMed
UniProtQ9KVM1|HEM3_VIBCH Porphobilinogen deaminase (Gene Name=hemC)

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