Structure of PDB 5guh Chain A Binding Site BS02

Receptor Information
>5guh Chain A (length=759) Species: 7091 (Bombyx mori) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ISILRTRPEAVTSKKGTSGTPLDLLANYFTVETTPKWGLYQYHVDISPEE
DSTGVRKALMRVHSKTLGGYLFDGTVLYTVNRLHPDPMELYSDRKTDNER
MRILIKLTCEVSPGDYHYIQIFNIIIRKCFNLLKLQLMGRDYFDPEAKID
IPEFKLQIWPGYKTTINQYEDRLLLVTEIAHKVLRMDTVLQMLSEYAATK
KIFLEDVVGKIVMTDYNKRTYRVDDVANVSPKSTFKMRDENITYIEYYYK
KYNLRIQDPGQPLLISRSKPREIRAGLPELIYLVPELCRQTGLSDEMRAN
FKLMRSLDVHTKIGPDKRIEKLNNFNRRFTSTPEVVEELATWSLKLSKEL
VKIKGRQLPPENIIQANNVKYPAGDTTEGWTRDMRSKHLLAIAQLNSWVV
ITPERQRRDTESFIDLIIKTGGGVGFRMRSPDLVVIRHDGPIEYANMCEE
VIARKNPALILCVLARNYADRYEAIKKKCTVDRAVPTQVVCARNMSSKSA
MSIATKVAIQINCKLGGSPWTVDIPLPSLMVVGYDVCHDTRSKEKSFGAF
VATLDKQMTQYYSIVNAHLSSHMGFNIASAVKKFREKNGTYPARIFIYRD
GVGDGQIPYVHSHEVAEIKKKLAEIYAGVEIKLAFIIVSKRINTRIFVQR
GRSGENPRPGTVIDDVVTLPERYDFYLVSQNVREGTIAPTSYNVIEDTTG
LNPDRIQRLTYKLTHLYFNCSSQVRVPSVCQYAHKLAFLAANSLHNQPHY
SLNETLYFL
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain5guh Chain A Residue 901 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5guh Crystal Structure of Silkworm PIWI-Clade Argonaute Siwi Bound to piRNA
Resolution2.4 Å
Binding residue
(original residue number in PDB)		Q645 L899
Binding residue
(residue number reindexed from 1)		Q510 L759
Annotation score4
Enzymatic activity
Enzyme Commision number 3.1.26.-
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0004521 RNA endonuclease activity
GO:0005515 protein binding
GO:0034584 piRNA binding
GO:0046872 metal ion binding
GO:0061980 regulatory RNA binding
Biological Process
GO:0007283 spermatogenesis
GO:0030154 cell differentiation
GO:0030237 female sex determination
GO:0031047 regulatory ncRNA-mediated gene silencing
GO:0034587 piRNA processing
GO:0051321 meiotic cell cycle
GO:0140965 secondary piRNA processing
GO:0140991 piRNA-mediated gene silencing by mRNA destabilization
Cellular Component
GO:0005737 cytoplasm
GO:0043186 P granule
GO:1990923 PET complex

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5guh, PDBe:5guh, PDBj:5guh
PDBsum5guh
PubMed27693359
UniProtA8D8P8|SIWI_BOMMO Piwi-like protein Siwi (Gene Name=Siwi)

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