Structure of PDB 5gof Chain A Binding Site BS02

Receptor Information

>5gof Chain A (length=390) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

PVSPLKHFVLAKKAITAIFDQLLEFVTEGSHFVEATYKNPELDRIATEDD
LVEMQGYKDKLSIIGEVLSRRHMKVAFFGRTSSGKSSVINAMLWDKVLPS
GIGHITNCFLSVEGTDGDKAYLMTEGSDEKKSVKTVNQLAHALHAGCLVR
VFWPKAKCALLRDDLVLVDSPGTDELDSWIDKFCLDADVFVLVANSESTL
MNTEKHFFHKVNERLSKPNIFILNNRWDASASEPEYMEDVRRQHMERCLH
FLVEELKVVNALEAQNRIFFVSAKEVLSARKQKVALAEGFHARLQEFQNF
EQIFEECISQSAVKTKFEQHTIRAKQILATVKNIMDSVNLAAEDKRHYSA
RLPKEIDQLEKIQNNSKLLRNKAVQLENELENFTKQFLPS

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

5gof Chain A Residue 903 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	5gof MFN1 structures reveal nucleotide-triggered dimerization critical for mitochondrial fusion
Resolution	1.604 Å
Binding residue (original residue number in PDB)	C111 H144 H147 C156
Binding residue (residue number reindexed from 1)	C108 H141 H144 C147
Annotation score	1

Enzymatic activity

Enzyme Commision number

3.6.5.-

Gene Ontology

	Molecular Function
GO:0003924	GTPase activity
GO:0005525	GTP binding

	Biological Process
GO:0008053	mitochondrial fusion

	Cellular Component
GO:0005741	mitochondrial outer membrane
GO:0016020	membrane

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Molecular Function

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Cellular Component

External links

PDB	RCSB:5gof, PDBe:5gof, PDBj:5gof
PDBsum	5gof
PubMed	28114303
UniProt	Q8IWA4\|MFN1_HUMAN Mitofusin-1 (Gene Name=MFN1)

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