Structure of PDB 5gne Chain A Binding Site BS02

Receptor Information

>5gne Chain A (length=366) Species: 272624 (Legionella pneumophila subsp. pneumophila str. Philadelphia 1)

EEDRIIVSNCLYEQLKDKARLIAQSDHFSFIAIPIDENITNTLQKMRPVC
GNYLNAEPYIQQTSNRFLDSKKLLDKLTSYHSIPYPINHEAQVHSLFEQI
DPAKIWQTNQHLTSYINRSAKSRTGVEAAQWFKQQFDTLAQDYGRKDVES
YFVKTGNKFIQPSVVTVIGKDKPGEAIVIGAHIDTLDGNMPGADDDSSGI
SVELEMARVVFSSNFELNRPIYFIAYAAEERGLIGSGYVVQDFLQKKIPV
KAVMQLDQAGYRANAKDQTIWLLKDYVDKGLTEFTAELLTRYVKTPVGYT
KCGYACSDHVNWTNEGFKTTYPSATTLDDDNPYVHTSNDTLDILNLEHMV
NFTKLGLAFIVELGLN

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 5gne Chain A Residue 402

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5gne Crystal Structure and Biochemical Characterization of an Aminopeptidase LapB from Legionella pneumophila.
• Resolution: 2.5 Å
• Binding residue (original residue number in PDB): H213 D226 D288
• Binding residue (residue number reindexed from 1): H182 D195 D257
• Annotation score: 4

Enzymatic activity

• Catalytic site (original residue number in PDB): H213 D226 E260 E261 D288 H366
• Catalytic site (residue number reindexed from 1): H182 D195 E229 E230 D257 H335

Gene Ontology

Molecular Function

• GO:0004177 aminopeptidase activity
• GO:0008235 metalloexopeptidase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006508 proteolysis

External links

• PDB: RCSB:5gne, PDBe:5gne, PDBj:5gne
• PDBsum: 5gne
• PubMed: 28776986
• UniProt: Q5ZZH8