Structure of PDB 5gk9 Chain A Binding Site BS02

Receptor Information

>5gk9 Chain A (length=265) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

MIKTIAFGRYELDTWYHSPYPEEYARLGRLYMCEFCLKYMKSQTILRRHM
AKCVWKHPPGDEIYRKGSISVFEVDGKKNKIYCQNLCLLAKLFLDHKTLY
YDVEPFLFYVMTEADNTGCHLIGYFSKEKNSFLNYNVSCILTMPQYMRQG
YGKMLIDFSYLLSKVEEKVGSPERPLSDLGLISYRSYWKEVLLRYLHNFQ
GKEISIKEISQETAVNPVDIVSTLQALQMLKYWKGKHLVLKRQDLIDEWI
SNKTMDPSCLKWTPP

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

5gk9 Chain A Residue 701 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	5gk9 Structural and mechanistic insights into regulation of HBO1 histone acetyltransferase activity by BRPF2.
Resolution	2.4 Å
Binding residue (original residue number in PDB)	C368 C371 H384 C388
Binding residue (residue number reindexed from 1)	C33 C36 H49 C53
Annotation score	1

Enzymatic activity

Catalytic site (original residue number in PDB)	C474 E508
Catalytic site (residue number reindexed from 1)	C139 E173
Enzyme Commision number	2.3.1.48: histone acetyltransferase.

Gene Ontology

	Molecular Function
GO:0004402	histone acetyltransferase activity

	Biological Process
GO:0006355	regulation of DNA-templated transcription

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Molecular Function

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Biological Process

External links

PDB	RCSB:5gk9, PDBe:5gk9, PDBj:5gk9
PDBsum	5gk9
PubMed	28334966
UniProt	O95251\|KAT7_HUMAN Histone acetyltransferase KAT7 (Gene Name=KAT7)

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