Structure of PDB 5giq Chain A Binding Site BS02

Receptor Information

>5giq Chain A (length=348) Species: 243230 (Deinococcus radiodurans R1 = ATCC 13939 = DSM 20539)

SSKMDQLRPVLGRAGVDALWVSAPANVRWLSGFTSAEDGKVLVSPDGATL
YTDARYTVQAQEESSLPQYIARPPATYEHAADTVRGLRVGFEAESLTVAE
LEDLRQAWPNSTLVALRGTLGGLRAVKTPEEIGAIRAAQDLADRVYTEVR
PMIRAGVRELDVAVEIETRLRRAGGESAFELIVASGPNGAKPHGHASKRV
IEDGDLVTIDMGARLGGYNSDMTRTVAVGTPSAEMKRVYDAVLEAEEAAI
AAIRPGVRAADLDKLARDLLTRHGLGEAFHSLGHGVGLEVHEGPGLRGTS
QDVLEAGMVITIEPGAYLPGVGGVRIEDLILVTEDGYEVLSHSAKESV

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 5giq Chain A Residue 403

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5giq Structures and activities of widely conserved small prokaryotic aminopeptidases-P clarify classification of M24B peptidases.
• Resolution: 1.8 Å
• Binding residue (original residue number in PDB): D210 D221 E328
• Binding residue (residue number reindexed from 1): D210 D221 E327
• Annotation score: 4

Enzymatic activity

• Catalytic site (original residue number in PDB): D82 H193 D210 D221 T223 H281 H285 H292 E314 Y318 R326 E328
• Catalytic site (residue number reindexed from 1): D82 H193 D210 D221 T223 H280 H284 H291 E313 Y317 R325 E327

Gene Ontology

Molecular Function

• GO:0004177 aminopeptidase activity
• GO:0008235 metalloexopeptidase activity
• GO:0016787 hydrolase activity
• GO:0046872 metal ion binding
• GO:0046914 transition metal ion binding

External links

• PDB: RCSB:5giq, PDBe:5giq, PDBj:5giq
• PDBsum: 5giq
• PubMed: 30536999
• UniProt: Q9RUY4