Structure of PDB 5g4a Chain A Binding Site BS02

Receptor Information

>5g4a Chain A (length=261) Species: 28901 (Salmonella enterica)

TLSIPPSIQCQTEAACRLITRVTGDTLRAIHLYGSAVAGGLKPNSDIDLL
VTICQPLTEAQRATLMQELLALSSPPGASAEKRALEVTVVLYSQLVPWCF
PPSREMQFGEWLREDICQGIYEPAQQDWDMVLLITQILETSIPLKGERAE
RLFTPAPAAQLLKALRYPLDLWQSTADVQGDEYHIVLTLARIWYTLSTGR
FTSKDAAADWLLPQLPEDYAATLRAAQREYLGLEQQDWHILLPAVVRFVD
FAKAHIPTQFT

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 5g4a Chain A Residue 3264

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5g4a Structural mechanism of AadA, a dual-specificity aminoglycoside adenylyltransferase fromSalmonella enterica.
• Resolution: 1.9 Å
• Binding residue (original residue number in PDB): D47 D49 E87
• Binding residue (residue number reindexed from 1): D46 D48 E86
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.7.7.47: streptomycin 3''-adenylyltransferase.

Gene Ontology

Molecular Function

• GO:0005524 ATP binding
• GO:0009012 aminoglycoside 3''-adenylyltransferase activity
• GO:0016779 nucleotidyltransferase activity
• GO:0046872 metal ion binding
• GO:0070566 adenylyltransferase activity

Biological Process

• GO:0046677 response to antibiotic

External links

• PDB: RCSB:5g4a, PDBe:5g4a, PDBj:5g4a
• PDBsum: 5g4a
• PubMed: 29871922
• UniProt: Q8ZPX9|S3AD_SALTY Aminoglycoside (3'') (9) adenylyltransferase (Gene Name=aadA)