Structure of PDB 5fy1 Chain A Binding Site BS02

Receptor Information

>5fy1 Chain A (length=442) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

KDKLNPPTPSIYLENKRDAFFPPLHQFCTNPKNPVTVIRGLAGALKLDLG
LFSTKTLVEANNEHMVEVRTQLLQPADENWDPTGTKKIWRCESNRSHTTI
AKYAQYQASSFQESLREENEKGPFKTIKFGTNIDLSDNKKWKLQLHELTK
LPAFARVVSAGNLLTHVGHTILGMNTVQLYMKVPGSRTPGHQENNNFCSV
NINIGPGDCEWFVVPEDYWGVLNDFCEKNNLNFLMSSWWPNLEDLYEANV
PVYRFIQRPGDLVWINAGTVHWVQAVGWCNNIAWNVGPLTACQYKLAVER
YEWNKLKSVKSPVPMVHLSWNMARNIKVSDPKLFEMIKYCLLKILKQYQT
LREALVAAGKEVIWHGRTNDEPAHYCSICEVEVFNLLFVTNESNTQKTYI
VHCHDCARKTSKSLENFVVLEQYKMEDLIQVYDQFTLALSLS

Ligand information

Ligand ID

InChI

InChI=1S/Mn/q+2

InChIKey

WAEMQWOKJMHJLA-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Mn+2]
CACTVS 3.341	[Mn++]

Formula

Name

MANGANESE (II) ION

PDB chain

5fy1 Chain A Residue 2346 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	5fy1 Crystal Structure of Jmjc Domain of Human Histone Demethylase Uty in Complex with N08619B
Resolution	1.78 Å
Binding residue (original residue number in PDB)	H1093 E1095 H1173
Binding residue (residue number reindexed from 1)	H191 E193 H271
Annotation score	1

Enzymatic activity

Enzyme Commision number

1.14.11.68: [histone H3]-trimethyl-L-lysine(27) demethylase.

External links

PDB	RCSB:5fy1, PDBe:5fy1, PDBj:5fy1
PDBsum	5fy1
PubMed
UniProt	O14607\|UTY_HUMAN Histone demethylase UTY (Gene Name=UTY)

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