Structure of PDB 5fxx Chain A Binding Site BS02

Receptor Information

>5fxx Chain A (length=444) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

KDKLNPPTPSIYLENKRDAFFPPLHQFCTNPKNPVTVIRGLAGALKLDLG
LFSTKTLVEANNEHMVEVRTQLLQPADENWDPTGTKKIWRCESNRSHTTI
AKYAQYQASSFQESLREENEKRKGPFKTIKFGTNIDLSDNKKWKLQLHEL
TKLPAFARVVSAGNLLTHVGHTILGMNTVQLYMKVPGSRTPGHQENNNFC
SVNINIGPGDCEWFVVPEDYWGVLNDFCEKNNLNFLMSSWWPNLEDLYEA
NVPVYRFIQRPGDLVWINAGTVHWVQAVGWCNNIAWNVGPLTACQYKLAV
ERYEWNKLKSVKSPVPMVHLSWNMARNIKVSDPKLFEMIKYCLLKILKQY
QTLREALVAAGKEVIWHGRTNDEPAHYCSICEVEVFNLLFVTNESNTQKT
YIVHCHDCARKTSKSLENFVVLEQYKMEDLIQVYDQFTLALSLS

Ligand information

Ligand ID

OAA

InChI

InChI=1S/C4H4O5/c5-2(4(8)9)1-3(6)7/h1H2,(H,6,7)(H,8,9)/p-1

InChIKey

KHPXUQMNIQBQEV-UHFFFAOYSA-M

SMILES

Software	SMILES
ACDLabs 10.04	[O-]C(=O)CC(=O)C(=O)O
OpenEye OEToolkits 1.5.0	C(C(=O)C(=O)O)C(=O)[O-]
CACTVS 3.341	OC(=O)C(=O)CC([O-])=O

Formula

C4 H3 O5

Name

OXALOACETATE ION

PDB chain

5fxx Chain A Residue 2346 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	5fxx Crystal Structure of Jmjc Domain of Human Histone Demethylase Uty in Complex with Oxaloacetate
Resolution	1.99 Å
Binding residue (original residue number in PDB)	Y1082 K1084 T1090 H1093 N1103 V1175 N1183
Binding residue (residue number reindexed from 1)	Y182 K184 T190 H193 N203 V275 N283
Annotation score	3

Enzymatic activity

Enzyme Commision number

1.14.11.68: [histone H3]-trimethyl-L-lysine(27) demethylase.

External links

PDB	RCSB:5fxx, PDBe:5fxx, PDBj:5fxx
PDBsum	5fxx
PubMed
UniProt	O14607\|UTY_HUMAN Histone demethylase UTY (Gene Name=UTY)

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