Structure of PDB 5fwa Chain A Binding Site BS02

Receptor Information

>5fwa Chain A (length=339) Species: 10090 (Mus musculus)

DTWQDEEYFDSYGTLKLHLEMLADQPRTTKYHSVILQNKESLKDKVILDV
GCGTGIISLFCAHHARPKAVYAVEASDMAQHTSQLVLQNGFADTITVFQQ
KVEDVVLPEKVDVLVSEWMGTCLLFEFMIESILYARDTWLKGDGIIWPTT
AALHLVPCSAEKDYHSKVLFWDNAYEFNLSALKSLAIKEFFSRPKSNHIL
KPEDCLSEPCTILQLDMRTVQVPDLETMRGELRFDIQKAGTLHGFTAWFS
VYFQSLEEGQPQQVLSTGPLHPTTHWKQTLFMMDDPVPVHTGDVVTGSVV
LQRNPVWRRHMSVSLSWVVTSALDPTSQRVGEKVFPIWW

Ligand information

• Ligand ID: CA
• InChI: InChI=1S/Ca/q+2
• InChIKey: BHPQYMZQTOCNFJ-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Ca++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Ca+2]
• Formula: Ca
• Name: CALCIUM ION
• DrugBank: DB14577
• PDB chain: 5fwa Chain A Residue 1452

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5fwa Structural studies of protein arginine methyltransferase 2 reveal its interactions with potential substrates and inhibitors.
• Resolution: 1.8 Å
• Binding residue (original residue number in PDB): G196 D199
• Binding residue (residue number reindexed from 1): G90 D93
• Annotation score: 4

Enzymatic activity

• Catalytic site (original residue number in PDB): D130 E223 E232 H381
• Catalytic site (residue number reindexed from 1): D24 E117 E126 H275
• Enzyme Commision number: 2.1.1.125: Transferred entry: 2.1.1.319, 2.1.1.320, 2.1.1.321 and 2.1.1.322.

Gene Ontology

Molecular Function

• GO:0008168 methyltransferase activity
• GO:0016274 protein-arginine N-methyltransferase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0018216 peptidyl-arginine methylation
• GO:0032259 methylation

External links

• PDB: RCSB:5fwa, PDBe:5fwa, PDBj:5fwa
• PDBsum: 5fwa
• PubMed: 27879050
• UniProt: Q3UKX1