Structure of PDB 5frn Chain A Binding Site BS02
Receptor Information
>5frn Chain A (length=367) Species:
11963
(Human spumaretrovirus) [
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DAELDQLLQGHYIKGYPKQYTYFLEDGKVKVSRPEGVKIIPPQSDRQKIV
LQAHNLAHTGREATLLKIANLYWWPNMRKDVVKQLGRCQQCLITNASNKA
SGPILRPDRPQKPFDKFFIDYIGPLPPSQGYLYVLVVVDGMTGFTWLYPT
KAPSTSATVKSLNVLTSIAIPKVIHSDQGAAFTSSTFAEWAKERGIHLEF
STPYHPQSSGKVERKNSDIKRLLTKLLVGRPTKWYDLLPVVQLALNNTYS
PVLKYTPHQLLFGIDSNTPFANQDTLDLTREEELSLLQEIRTSLYHPSTP
PASSRSWSPVVGQLVQERVARPASLRPRWHKPSTVLKVLNPRTVVILDHL
GNNRTVSIDNLKPTSHQ
Ligand information
>5frn Chain D (length=17) [
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tgcgaaattccatgaca
Receptor-Ligand Complex Structure
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PDB
5frn
HIV-1 Integrase Strand Transfer Inhibitors with Reduced Susceptibility to Drug Resistant Mutant Integrases.
Resolution
2.85 Å
Binding residue
(original residue number in PDB)
E221 R222 K228 K262
Binding residue
(residue number reindexed from 1)
E213 R214 K220 K254
Enzymatic activity
Enzyme Commision number
2.7.7.-
2.7.7.49
: RNA-directed DNA polymerase.
2.7.7.7
: DNA-directed DNA polymerase.
3.1.-.-
3.1.26.4
: ribonuclease H.
3.4.23.-
Gene Ontology
Molecular Function
GO:0003676
nucleic acid binding
Biological Process
GO:0015074
DNA integration
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Molecular Function
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Biological Process
External links
PDB
RCSB:5frn
,
PDBe:5frn
,
PDBj:5frn
PDBsum
5frn
PubMed
26808478
UniProt
P14350
|POL_FOAMV Pro-Pol polyprotein (Gene Name=pol)
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