Structure of PDB 5flv Chain A Binding Site BS02

Receptor Information
>5flv Chain A (length=226) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PRVLFSQAQVYELERRFKQQRYLSAPERDQLASVLKLTSTQVKIWFQNRR
YKGIKVFLHERELWLKFHEVGTEMIITKAGRRMFPSYKVKVTGLNPKTKY
ILLMDIVPADDHRYKFADNKWSVTGKAEPAMPGRLYVHPDSPATGAHWMR
QLVSFQKLKLTNNHLDPFGHIILNSMHKYQPRLHIVKADSTHVFPETAFI
AVTSYQNHKITQLKIENNPFAKGFRG
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB5flv Complex Interdependence Regulates Heterotypic Transcription Factor Distribution and Coordinates Cardiogenesis.
Resolution3.005 Å
Binding residue
(original residue number in PDB)		Y161 Q186 R189 Y190 R1081 R1082 Y1217 T1223 K1226 F1232 F1236
Binding residue
(residue number reindexed from 1)		Y22 Q47 R50 Y51 R81 R82 Y205 T211 K214 F220 F224
Binding affinityPDBbind-CN: Kd~50nM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0045893 positive regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5flv, PDBe:5flv, PDBj:5flv
PDBsum5flv
PubMed26875865
UniProtP42582;
P70326

[Back to BioLiP]