Structure of PDB 5fer Chain A Binding Site BS02

Receptor Information
>5fer Chain A (length=79) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MAELCPLAEELSCSICLEPFKEPVTTPCGHNFCGSCLNETWAVQGSPYLC
PQCRAVYQARPQLHKNTVLCNVVEQFLQA
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain5fer Chain A Residue 102 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB5fer Functional role of TRIM E3 ligase oligomerization and regulation of catalytic activity.
Resolution2.34 Å
Binding residue
(original residue number in PDB)		C28 H30 C50
Binding residue
(residue number reindexed from 1)		C28 H30 C50
Annotation score4
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
6.3.2.n3: ISG15--protein ligase.
External links
PDB RCSB:5fer, PDBe:5fer, PDBj:5fer
PDBsum5fer
PubMed27154206
UniProtQ14258|TRI25_HUMAN E3 ubiquitin/ISG15 ligase TRIM25 (Gene Name=TRIM25)

[Back to BioLiP]