Structure of PDB 5f84 Chain A Binding Site BS02

Receptor Information
>5f84 Chain A (length=365) Species: 7227 (Drosophila melanogaster) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NEDEFSFKIRRQIEKANADYKPCSSDPQDSDCSCHANVLKRDLAPYKSTG
VTRQMIESSARYGTKYKIYGHRLYRDANCMFPARCEGIEHFLLPLVATLP
DMDLIINTRDYPQLNAAWGNAAGGPVFSFSKTKEYRDIMYPAWTFWAGGP
ATKLHPRGIGRWDQMREKLEKRAAAIPWSQKRSLGFFRGSRTSDERDSLI
LLSRRNPELVEAQYTKNQGWKSPKDTLDAPAADEVSFEDHCKYKYLFNFR
GVAASFRLKHLFLCKSLVFHVGDEWQEFFYDQLKPWVHYVPLKSYPSQQE
YEHILSFFKKNDALAQEIAQRGYDFIWEHLRMKDIKCYWRKLLKRYVKLL
QYEVKPEDQLIYIGP
Ligand information
Ligand IDBGC
InChIInChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6-/m1/s1
InChIKeyWQZGKKKJIJFFOK-VFUOTHLCSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.6C(C1C(C(C(C(O1)O)O)O)O)O
CACTVS 3.370OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O
CACTVS 3.370OC[CH]1O[CH](O)[CH](O)[CH](O)[CH]1O
OpenEye OEToolkits 1.7.6C([C@@H]1[C@H]([C@@H]([C@H]([C@@H](O1)O)O)O)O)O
ACDLabs 12.01OC1C(O)C(OC(O)C1O)CO
FormulaC6 H12 O6
Namebeta-D-glucopyranose;
beta-D-glucose;
D-glucose;
glucose
ChEMBLCHEMBL1614854
DrugBankDB02379
ZINCZINC000003833800
PDB chain5f84 Chain B Residue 101 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5f84 Structural analysis of Notch-regulating Rumi reveals basis for pathogenic mutations.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		D151 V293 A294 A295 F297
Binding residue
(residue number reindexed from 1)		D110 V252 A253 A254 F256
Annotation score1
Enzymatic activity
Enzyme Commision number 2.4.1.-
Gene Ontology
Molecular Function
GO:0016757 glycosyltransferase activity
GO:0035251 UDP-glucosyltransferase activity
GO:0035252 UDP-xylosyltransferase activity
GO:0046527 glucosyltransferase activity
GO:0140561 EGF-domain serine glucosyltransferase activity
GO:0140562 EGF-domain serine xylosyltransferase activity
Biological Process
GO:0006486 protein glycosylation
GO:0006493 protein O-linked glycosylation
GO:0007219 Notch signaling pathway
GO:0018242 protein O-linked glycosylation via serine
GO:0042052 rhabdomere development
GO:0045165 cell fate commitment
GO:0045746 negative regulation of Notch signaling pathway
GO:0045747 positive regulation of Notch signaling pathway
GO:0060537 muscle tissue development
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen
GO:0012505 endomembrane system

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5f84, PDBe:5f84, PDBj:5f84
PDBsum5f84
PubMed27428513
UniProtQ8T045|RUMI_DROME O-glucosyltransferase rumi (Gene Name=rumi)

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