Structure of PDB 5e6a Chain A Binding Site BS02

Receptor Information

>5e6a Chain A (length=73) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

PKLCLVCSDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDK
IRRKNCPACRYRKCLQAGMNLEA

Ligand information

>5e6a Chain D (length=16) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

atcaggaaattcccag

Receptor-Ligand Complex Structure

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PDB	5e6a Cryptic glucocorticoid receptor-binding sites pervade genomic NF-kappa B response elements.
Resolution	2.197 Å
Binding residue (original residue number in PDB)	S440 F444 R447 R470 K471 R477
Binding residue (residue number reindexed from 1)	S23 F27 R30 R53 K54 R60
Binding affinity	PDBbind-CN: Kd>50uM

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003700	DNA-binding transcription factor activity
GO:0008270	zinc ion binding
GO:0043565	sequence-specific DNA binding

	Biological Process
GO:0006355	regulation of DNA-templated transcription

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External links

PDB	RCSB:5e6a, PDBe:5e6a, PDBj:5e6a
PDBsum	5e6a
PubMed	29626214
UniProt	P04150\|GCR_HUMAN Glucocorticoid receptor (Gene Name=NR3C1)

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