Structure of PDB 5e3u Chain A Binding Site BS02

Receptor Information
>5e3u Chain A (length=302) Species: 7955 (Danio rerio) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TTSSALKGAIQLGITHSVGSLSQKPERDVLMQDFEVVESIFFPSQGSSST
PGHHHGDFKFKTYAPIAFRYFREMFGIRPDDYLYSLCNEPLIELSNGSLF
YVSSDDEFIIKTVQHKEAEFLQTLLPGYFMNLNQNMRTLLPKFYGLYCVQ
ADGKNIRIVVMNNLLPRAVPMHLKFDLKGSTYKRRASPKERSKGVPTYKD
LDFMQDMPEGILLENDHYTALSRTMQRDCRVLQSFKIMDYSLLVGIHILH
MGGIPAFNSKGERLLVFIGIIDILQSYRSVHRPSFYADRFQKFMCSTVFR
KS
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain5e3u Chain A Residue 502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5e3u Mechanism of substrate specificity of phosphatidylinositol phosphate kinases.
Resolution3.6 Å
Binding residue
(original residue number in PDB)		D299 D378
Binding residue
(residue number reindexed from 1)		D239 D272
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) K171 D299
Catalytic site (residue number reindexed from 1) K111 D239
Enzyme Commision number 2.7.1.68: 1-phosphatidylinositol-4-phosphate 5-kinase.
Gene Ontology
Molecular Function
GO:0052742 phosphatidylinositol kinase activity
Biological Process
GO:0046488 phosphatidylinositol metabolic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5e3u, PDBe:5e3u, PDBj:5e3u
PDBsum5e3u
PubMed27439870
UniProtQ503I3

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