Structure of PDB 5e3l Chain A Binding Site BS02

Receptor Information
>5e3l Chain A (length=91) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SDVLTVSTVNSQDQVTQKPLRDSVKQALKNYFAQLNGQDVNDLYELVLAE
VEQPLLDMVMQYTRGNQTRAALMMGINRGTLRKKLKKYGMN
Ligand information
Receptor-Ligand Complex Structure
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PDB5e3l DNA Sequence Determinants Controlling Affinity, Stability and Shape of DNA Complexes Bound by the Nucleoid Protein Fis.
Resolution2.66 Å
Binding residue
(original residue number in PDB)		N73 Q74 T75 R85 R89
Binding residue
(residue number reindexed from 1)		N66 Q67 T68 R78 R82
Binding affinityPDBbind-CN: Kd=30nM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000976 transcription cis-regulatory region binding
GO:0001046 core promoter sequence-specific DNA binding
GO:0001216 DNA-binding transcription activator activity
GO:0001217 DNA-binding transcription repressor activity
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
GO:0043565 sequence-specific DNA binding
GO:0044374 sequence-specific DNA binding, bending
Biological Process
GO:0006351 DNA-templated transcription
GO:0006355 regulation of DNA-templated transcription
GO:0009314 response to radiation
GO:0032359 provirus excision
GO:0045892 negative regulation of DNA-templated transcription
GO:0045893 positive regulation of DNA-templated transcription
GO:0045911 positive regulation of DNA recombination
GO:0051276 chromosome organization
Cellular Component
GO:0000786 nucleosome
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0009295 nucleoid
GO:0031421 invertasome
GO:0032993 protein-DNA complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5e3l, PDBe:5e3l, PDBj:5e3l
PDBsum5e3l
PubMed26959646
UniProtP0A6R3|FIS_ECOLI DNA-binding protein Fis (Gene Name=fis)

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