Structure of PDB 5e3h Chain A Binding Site BS02

Receptor Information
>5e3h Chain A (length=642) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FKPRNYQLELALPAMKGKNTIICAPTGCGKTFVSLLICEHHLKKFPQGQK
GKVVFFANQIPVYEQQKSVFSKYFERHGYRVTGISGATAENVPVEQIVEN
NDIIILTPQILVNNLKKGTIPSLSIFTLMIFDECHNTSKQHPYNMIMFNY
LDQKLGGSSGPLPQVIGLTASVGVGDAKNTDEALDYICKLCASLDASVIA
TVKHNLEELEQVVYKPQKFFRKVESRISDKFKYIIAQLMRDTESLAKRIC
KDLEFGTQKYEQWIVTVQKACMVFDKDEESRICKALFLYTSHLRKYNDAL
IISEHARMKDALDYLKDFFSNVRAEIEQDLTQRFEEKLQELESVSRDPSN
ENPKLEDLCFILQEEYHLNPETITILFVKTRALVDALKNWIEGNPKLSFL
KPGILTGRGTGMTLPAQKCILDAFKDHNILIATSVADEGIDIAQCNLVIL
YEYVGNVIKMIQTRGRGRARGSKCFLLTSNAGVIEKEQINMYKEKMMNDS
ILRLQTWDEAVFREKILHIQTHEKFIRDSQEVPDKENKKLLCRKCKALAC
YTADVRVIEECHYTVLGDAFKECFVSRPHPKPKQFSSFEKRAKIFCARCS
HDWGIHVKYKTFEIPVIKIESFTLYSKWKDFHFEKIPFDPAE
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5e3h Structural basis of RNA recognition and activation by innate immune receptor RIG-I.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		N298 I300 S325 G326 T347 Q349 E510 K635 T636 R637 G663 R664 T697 S698 V699 F853 S906
Binding residue
(residue number reindexed from 1)		N58 I60 S85 G86 T107 Q109 E261 K379 T380 R381 G407 R408 T433 S434 V435 F585 S626
Binding affinityPDBbind-CN: Kd=0.02nM
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:5e3h, PDBe:5e3h, PDBj:5e3h
PDBsum5e3h
PubMed21947008
UniProtO95786|RIGI_HUMAN Antiviral innate immune response receptor RIG-I (Gene Name=RIGI)

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